Nobukuni K, Hayakawa N, Namba R, Ihara Y, Sato K, Takada H, Hayabara T, Kawahara S
Department of Neurology, National Sanatorium Minami-Okayama Hospital, Japan.
Dermatology. 1997;195 Suppl 2:69-72. doi: 10.1159/000246034.
Povidone-iodine (PVP-I) is generally very safe, but cases of thyroid dysfunction induced by PVP-I have been reported. The effect of long-term treatment with PVP-I on thyroid function was to be assessed. In 40 inpatients of the department of neurology, the status of the use of PVP-I preparations and their effects on serum inorganic iodine levels and thyroid functions were investigated. In 27 patients treated with PVP-I for a long term, inorganic iodine levels were significantly increased as compared to those in 13 patients without PVP-I treatment. Out of 27 patients treated with PVP-I in the long term, subclinical hypothroidism was seen in 3 patients, mild hyperthroidism was seen in 1 patient, and subclinical hyperthyroidism was suspected in 7 patients. Patients treated with PVP-I for a long time should be observed carefully for any manifestation of thyroid dysfunction.
聚维酮碘（PVP-I）通常非常安全，但已有聚维酮碘诱发甲状腺功能障碍的病例报道。本研究旨在评估长期使用聚维酮碘对甲状腺功能的影响。对神经内科40例住院患者，调查聚维酮碘制剂的使用情况及其对血清无机碘水平和甲状腺功能的影响。27例长期接受聚维酮碘治疗的患者与13例未接受聚维酮碘治疗的患者相比，无机碘水平显著升高。27例长期接受聚维酮碘治疗的患者中，3例出现亚临床甲状腺功能减退，1例出现轻度甲状腺功能亢进，7例疑似亚临床甲状腺功能亢进。长期接受聚维酮碘治疗的患者应密切观察有无甲状腺功能障碍的表现。
