Armstrong J, Challenor V F, Macklin B S, Renwick A G, Waller D G
Clinical Pharmacology/Medicine Group, Southampton General Hospital, United Kingdom.
Eur J Clin Pharmacol. 1997;53(2):141-3. doi: 10.1007/s002280050352.
The effect of two different types of meal on the absorption of a modified-release formulation of nifedipine (Adalat Retard) was studied.
A light breakfast produced a delay in gastric emptying (indicated by the rate of paracetamol absorption) compared with the fasting state but did not alter the tmax or Cmax for nifedipine significantly. After a cooked breakfast, there was less delay in gastric emptying and again no delay in tmax for nifedipine. However, the Cmax for nifedipine was significantly higher than in the fasting state. Neither meal influenced the bioavailability of nifedipine.
The results suggest that the nature of the meal has an important influence on the absorption profile of this formulation of nifedipine, probably by an effect on its dissolution. This study illustrates the importance of considering the effects of different types of meal before concluding that food does not affect the pattern of drug absorption.
研究两种不同类型的膳食对硝苯地平缓释制剂（拜新同缓释片）吸收的影响。
与空腹状态相比，清淡早餐使胃排空延迟（以对乙酰氨基酚吸收速率表示），但对硝苯地平的达峰时间（tmax）或血药浓度峰值（Cmax）无显著影响。食用熟食早餐后，胃排空延迟较少，硝苯地平的达峰时间也无延迟。然而，硝苯地平的血药浓度峰值显著高于空腹状态。两种膳食均未影响硝苯地平的生物利用度。
结果表明，膳食的性质对该硝苯地平制剂的吸收情况有重要影响，可能是通过影响其溶解来实现的。本研究说明了在得出食物不影响药物吸收模式的结论之前，考虑不同类型膳食影响的重要性。
