人类疱疹病毒8编码一种干扰素调节因子（IRF）同源物，该同源物可抑制IRF-1介导的转录。
Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription.
作者信息
Zimring J C, Goodbourn S, Offermann M K
机构信息
Winship Cancer Center, Emory University, Atlanta, Georgia 30322, USA.
出版信息
J Virol. 1998 Jan;72(1):701-7. doi: 10.1128/JVI.72.1.701-707.1998.
Abstract
Human herpesvirus 8 (HHV-8) is the probable viral etiologic agent for Kaposi's sarcoma. The HHV-8 genome encodes viral interferon regulatory factor (vIRF), a gene product that has homology to the IRF family of transcription factors. We demonstrate that vIRF inhibits responses to type I and type II interferons and blocks IRF-1-mediated transcription. vIRF does not compete with IRF-1 for binding to DNA or complex directly with IRF-1. The ability of vIRF to block IRF-1-mediated transcription is independent of the DNA binding domains of both vIRF and IRF-1. These data suggest that vIRF may contribute to viral pathogenesis and cellular transformation by interfering with interferon- and IRF-1-mediated gene expression through a novel mechanism.
摘要
人类疱疹病毒8型（HHV - 8）可能是卡波西肉瘤的病毒病原体。HHV - 8基因组编码病毒干扰素调节因子（vIRF），该基因产物与转录因子IRF家族具有同源性。我们证明vIRF抑制对I型和II型干扰素的反应，并阻断IRF - 1介导的转录。vIRF不与IRF - 1竞争结合DNA，也不直接与IRF - 1形成复合物。vIRF阻断IRF - 1介导转录的能力独立于vIRF和IRF - 1的DNA结合结构域。这些数据表明，vIRF可能通过一种新机制干扰干扰素和IRF - 1介导的基因表达，从而促进病毒发病机制和细胞转化。
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本文引用的文献
1
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14862-7. doi: 10.1073/pnas.93.25.14862.
2
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.
Science. 1996 Dec 6;274(5293):1739-44. doi: 10.1126/science.274.5293.1739.
3
Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.
Genomics. 1996 Oct 15;37(2):229-33. doi: 10.1006/geno.1996.0547.
4
Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma.
J Virol. 1996 Nov;70(11):8218-23. doi: 10.1128/JVI.70.11.8218-8223.1996.
5
Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.
Infect Agents Dis. 1996 Oct;5(4):215-22.
6
Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias.
Oncogene. 1996 Apr 4;12(7):1593-6.
7
Kaposi's sarcoma-associated herpesvirus and Kaposi's sarcoma in Africa. Uganda Kaposi's Sarcoma Study Group.
Arch Intern Med. 1996 Jan 22;156(2):202-4.
8
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11657-61. doi: 10.1073/pnas.92.25.11657.
9
Interleukin-6 activates and regulates transcription factors of the interferon regulatory factor family in M1 cells.
J Biol Chem. 1993 Apr 25;268(12):9092-7.
10
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2.
Science. 1993 Feb 12;259(5097):971-4. doi: 10.1126/science.8438157.
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