大鼠脑室内注射酚苄明的行为学效应。
Behavioral effects of phenoxybenzamine administered intraventricularly in rats.
作者信息
Zebrowska-Lupina I
出版信息
Arch Immunol Ther Exp (Warsz). 1976;24(2):223-31.
Phenoxybenzamine (PNB) injected into the lateral ventricle of the brain weakens spontaneous motility of rats and antagonizes hyperactivity induced with noradrenaline, amphetamine and caffeine. Body temperature rises briefly, sleep induced with chloral hydrate is shortened, and high doses enhance amphetamine-induced stereotypy. PNB injected intraventricularly intensifies turnover of noradrenaline but it has no effect on turnover of dopamine in rat brains. The results confirm a blocking influence of PNB on the cerebral noradrenaline receptors.
将苯氧苄胺（PNB）注入大鼠脑侧脑室会减弱大鼠的自发运动，并拮抗去甲肾上腺素、苯丙胺和咖啡因诱导的多动。体温会短暂升高，水合氯醛诱导的睡眠会缩短，高剂量时会增强苯丙胺诱导的刻板行为。脑室内注射PNB会增强去甲肾上腺素的更新，但对大鼠脑内多巴胺的更新没有影响。结果证实了PNB对脑内去甲肾上腺素受体的阻断作用。
Zotero 插件