Radiation-induced tumors in irradiated stage I testicular seminoma: results of a 25-year follow-up (1968-1993).
作者信息
Stein M E, Leviov M, Drumea K, Moshkovitz B, Nativ O, Milstein D, Sabo E, Kuten A
机构信息
Northern Israel Oncology Center, Rambam Medical Center, Haifa, Israel.
出版信息
J Surg Oncol. 1998 Jan;67(1):38-40. doi: 10.1002/(sici)1096-9098(199801)67:1<38::aid-jso8>3.0.co;2-n.
BACKGROUND AND OBJECTIVES
Testicular seminoma is a very radiosensitive and curable cancer, with survival rates following radiation therapy within the range of 90-98% without apparent severe side effects. However, long-term survival following exposure to moderate-dose radiation therapy can result in radiation-induced tumors.
METHODS
The incidence of radiation-induced tumors was determined in 81 irradiated stage I testicular seminoma patients treated at the Northern Israel Oncology Center (NIOC) from 1968 through 1993.
RESULTS
Three (4%) patients developed second cancers within the high-dose volume. Indeed, those patients received a higher than usual dose to the para-aortic and pelvic regions. One patient, who developed inoperable pancreatic carcinoma, was treated with "hockey stick" field and mediastinal irradiation, plus, as a result of relapses, multiple cisplatin and VP-16 based regimens.
CONCLUSIONS
The elimination of causative factors through lower total doses and field size reduction may reduce the, albeit very low, incidence of radiation-induced cancer in cured testicular seminoma.
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