A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13.
作者信息
Mathis B J, Kim S H, Calabrese K, Haas M, Seidman J G, Seidman C E, Pollak M R
机构信息
Department of Medicine, Oklahoma State University College of Osteopathic Medicine, Tulsa, USA.
出版信息
Kidney Int. 1998 Feb;53(2):282-6. doi: 10.1046/j.1523-1755.1998.00828.x.
Abstract
We performed a genome-wide linkage analysis search for a genetic locus responsible for kidney dysfunction in a large family. This inherited condition, characterized by proteinuria, progressive renal insufficiency, and focal segmental glomerulosclerosis, follows autosomal dominant inheritance. We show with a high degree of certainty (maximum 2-point lod score 12.28) that the gene responsible for this condition is located on chromosome 19q13.
摘要
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