低至中度吸烟和饮酒对血清免疫球蛋白浓度的影响。
Effect of low to moderate levels of smoking and alcohol consumption on serum immunoglobulin concentrations.
作者信息
McMillan S A, Douglas J P, Archbold G P, McCrum E E, Evans A E
机构信息
Regional Immunology Service, Royal Group of Hospitals, Belfast, UK.
出版信息
J Clin Pathol. 1997 Oct;50(10):819-22. doi: 10.1136/jcp.50.10.819.
AIM
To determine the effect of low to moderate levels of smoking and alcohol consumption on immunoglobulin concentrations.
METHODS
Serum samples from 1787 subjects with approximately equal numbers in each five year group from 15 to 64 years were obtained from a large random population survey in Northern Ireland. Details were available on each subject concerning the number of units of alcohol consumed per week and the number of cigarettes smoked per day. IgG, IgM, and IgA concentrations were measured by laser nephelometry on all serum samples.
RESULTS
Low to moderate consumption of alcohol was associated with a decrease in IgG and IgM median concentrations in contrast to an increase in IgA median concentrations. The decrease in IgM and especially IgG median concentrations appeared to be related to the smoking habits of the subjects. Alcohol consumption alone was associated with increased IgA median concentrations whereas cigarette smoking alone was associated with reduced IgG median concentrations.
CONCLUSION
Low levels of alcohol consumption and cigarette smoking influence IgG, IgM, and IgA serum concentrations. This should be borne in mind when selecting subjects for use in research and clinical settings.
目的
确定低至中等水平的吸烟和饮酒对免疫球蛋白浓度的影响。
方法
从北爱尔兰一项大型随机人群调查中获取了1787名受试者的血清样本，这些受试者年龄在15至64岁之间，按每五年一组划分，每组人数大致相等。记录了每位受试者每周饮酒的单位数量和每天吸烟的数量。所有血清样本均采用激光散射比浊法测量IgG、IgM和IgA浓度。
结果
与IgA中位数浓度增加相反，低至中等量饮酒与IgG和IgM中位数浓度降低有关。IgM尤其是IgG中位数浓度的降低似乎与受试者的吸烟习惯有关。单独饮酒与IgA中位数浓度增加有关，而单独吸烟与IgG中位数浓度降低有关。
结论
低水平的饮酒和吸烟会影响IgG、IgM和IgA的血清浓度。在选择用于研究和临床的受试者时应牢记这一点。
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