Sleijfer S, Vujaskovic Z, Limburg P C, Schraffordt Koops H, Mulder N H
Department of Medical Oncology, University Hospital, Groningen, The Netherlands.
Cancer. 1998 Mar 1;82(5):970-4. doi: 10.1002/(sici)1097-0142(19980301)82:5<970::aid-cncr24>3.0.co;2-x.
The application of bleomycin is characterized by acute side effects, such as fever, chills, and sometimes hypotension and tachypnea. Furthermore, bleomycin is known to induce pneumonitis. There are several indications that the induction of cytokines by bleomycin is involved in the development of these side effects.
In this study, the authors determined the plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and transforming growth factor-beta (TGF-beta) before and after bleomycin infusion in 14 patients treated for disseminated nonseminomatous germ cell tumor.
Compared with the pretreatment value, TNF-alpha was significantly increased 3, 4.5, and 24 hours after bleomycin infusion. For IL-1beta and TGF-beta, no significant alterations were observed within 24 hours after administration of bleomycin.
The increase in TNF-alpha after administration of bleomycin suggests a role for this cytokine in the development of the acute side effects and probably also in the occurrence of bleomycin-induced pulmonary toxicity. The involvement of IL-1beta and TGF-beta deserve further study.
博来霉素的应用具有急性副作用的特点，如发热、寒战，有时还会出现低血压和呼吸急促。此外，已知博来霉素会诱发肺炎。有若干迹象表明，博来霉素诱导细胞因子与这些副作用的发生有关。
在本研究中，作者测定了14例接受播散性非精原细胞瘤性生殖细胞肿瘤治疗的患者在输注博来霉素前后血浆中肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和转化生长因子-β（TGF-β）的水平。
与治疗前的值相比，博来霉素输注后3小时、4.5小时和24小时TNF-α显著升高。对于IL-1β和TGF-β，在给予博来霉素后24小时内未观察到显著变化。
博来霉素给药后TNF-α升高表明该细胞因子在急性副作用的发生中起作用，可能也与博来霉素诱导的肺毒性的发生有关。IL-1β和TGF-β的作用值得进一步研究。
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