Gannedahl P, Edner M, Ljungqvist O
Department of Anaesthesiology and Intensive Care, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
J Cardiothorac Vasc Anesth. 1998 Feb;12(1):38-44. doi: 10.1016/s1053-0770(98)90053-2.
To elucidate the relation of changes in computerized vectorcardiographic trend parameters indicating perioperative myocardial ischemia with perioperative cardiac complications.
Prospective clinical study.
A single university hospital.
Thirty-eight patients undergoing elective abdominal aortic surgery.
Computerized vectorcardiography recorded during surgery and for 48 hours postoperatively.
Vectorcardiographic spatial alterations in the QRS complex (QRS-VD) and absolute (ST-VM) and spatial (STC-VM) ST-segment changes, previously used indicators of myocardial ischemia, were analyzed and related to the cardiac events detected clinically. In five patients with clearly ischemic (cardiac death, myocardial infarction, recurrent ischemia) and eight patients with possibly ischemic (congestive heart failure, arrhythmia) perioperative cardiac events, ST-VM and STC-VM were significantly increased intraoperatively. Postoperatively, these differences remained, but QRS-VD were also significantly increased. Intraoperative and postoperative changes indicating ischemia were strongly related (r = 0.83). The signs of ischemia were most pronounced during the postoperative 12 to 36 hours. The presence of 60 minutes of signs of ischemia during 2 hours revealed high sensitivity (85%), specificity (80%), and positive (69%) and negative (91%) predictive values for subsequent cardiac events. Traditional vector loop analysis showed signs of non-Q-wave infarctions in six patients, whereas only three of these were detected using standard clinical methods.
Vectorcardiographic signs of myocardial ischemia were significantly increased intraoperatively, but most pronounced postoperatively in the patients subsequently suffering cardiac events. The changes could be related to the individual cardiac morbidity with acceptable precision. Thus, continuous vectorcardiographic monitoring may be beneficial for patients at risk of developing perioperative ischemia.
阐明提示围手术期心肌缺血的计算机向量心电图趋势参数变化与围手术期心脏并发症之间的关系。
前瞻性临床研究。
一家大学医院。
38例接受择期腹主动脉手术的患者。
手术期间及术后48小时进行计算机向量心电图记录。
分析了QRS波群的向量心电图空间改变(QRS-VD)以及绝对(ST-VM)和空间(STC-VM)ST段改变(以前用于心肌缺血的指标),并将其与临床检测到的心脏事件相关联。在5例有明确缺血性围手术期心脏事件(心源性死亡、心肌梗死、复发性缺血)的患者和8例可能有缺血性围手术期心脏事件(充血性心力衰竭、心律失常)的患者中,术中ST-VM和STC-VM显著增加。术后,这些差异仍然存在,但QRS-VD也显著增加。提示缺血的术中及术后变化密切相关(r = 0.83)。缺血迹象在术后12至36小时最为明显。2小时内出现60分钟缺血迹象对后续心脏事件具有高敏感性(85%)、特异性(80%)、阳性预测值(69%)和阴性预测值(91%)。传统向量环分析显示6例患者有非Q波梗死迹象,而使用标准临床方法仅检测到其中3例。
心肌缺血的向量心电图迹象在术中显著增加,但在随后发生心脏事件的患者中术后最为明显。这些变化与个体心脏发病率的相关性具有可接受的精确度。因此,持续的向量心电图监测可能对有围手术期缺血风险的患者有益。