主观症状与干眼及口干客观检测之间的弱关联：一项基于人群的研究结果
Weak association between subjective symptoms or and objective testing for dry eyes and dry mouth: results from a population based study.
作者信息
Hay E M, Thomas E, Pal B, Hajeer A, Chambers H, Silman A J
机构信息
Staffordshire Rheumatology Centre, Stoke on Trent.
出版信息
Ann Rheum Dis. 1998 Jan;57(1):20-4. doi: 10.1136/ard.57.1.20.
OBJECTIVES
To determine associations between symptoms of dry eyes and dry mouth and objective evidence of lacrimal and salivary gland dysfunction in a population based sample. To determine associations between these elements and the presence of autoantibodies.
METHODS
A cross sectional population based survey. Subjects were interviewed and examined (Schirmer-1 test and unstimulated salivary flow) for the presence of dry eyes and mouth. Antibodies (anti-Ro [SS-A], anti-La [SS-B], rheumatoid factor, antinuclear antibody) were measured.
RESULTS
341 subjects were examined. Twenty four per cent had dry eye symptoms, 29% dry mouth symptoms, and 14% both. There was only a weak association between the presence of oral or ocular symptoms and their respective test results. Associations were strongest between dry mouth symptoms and positive test results, and in subjects under 55 years of age. There was no association between the presence of autoantibodies and either symptoms or signs of dry eyes or dry mouth.
CONCLUSION
Only weak associations were found between self reported symptoms of dry eyes and dry mouth and objective measures said to define Sjögrens syndrome in the general population. The clinical significance of these symptoms in the community needs reappraisal.
目的
在基于人群的样本中确定干眼和口干症状与泪腺及唾液腺功能障碍客观证据之间的关联。确定这些因素与自身抗体存在之间的关联。
方法
一项基于人群的横断面调查。对受试者进行访谈并检查（施密特-1试验和非刺激性唾液流量）是否存在干眼和口干情况。检测抗体（抗Ro[SS-A]、抗La[SS-B]、类风湿因子、抗核抗体）。
结果
检查了341名受试者。24%有干眼症状，29%有口干症状，14%两者皆有。口腔或眼部症状的存在与其各自的检测结果之间仅有微弱关联。口干症状与阳性检测结果之间的关联最强，且在55岁以下的受试者中也是如此。自身抗体的存在与干眼或口干的症状或体征之间无关联。
结论
在一般人群中，自我报告的干眼和口干症状与据称可定义干燥综合征的客观指标之间仅发现微弱关联。这些症状在社区中的临床意义需要重新评估。
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