Goh C L, Ang C B, Chan R K, Cheong W K
National Skin Centre, Singapore.
Singapore Med J. 1998 Jan;39(1):17-9.
The aims of this study were to: 1) ascertain if podophyllin resin in 0.5% [PE(0.5%)] and 0.25% [PE(0.25%)] in ethanol (PE) self-applied sequentially for 3 days with 4 days break cycle is as effective as supervised podophyllin 25% in tincture benzoin (PB) applied in the clinic biweekly in treating penile warts and 2) ascertain if PE causes less skin irritation than PB.
The clearance rate of penile warts was 36.4% (4/11) in PE (0.5%) treated group, 66.7% (4/6) in the PE (0.25%) treated group and 33.3% (6/18) for PB treated group after 1 week (ns). The wart clearance rate at 6 weeks for PE (0.5%) treated group, PE (0.25%) treated group and PB treated group were 81.8% (9/11), 100% (6/6) and 83.3% (15/17) respectively (ns). There were 47 individual warts on the penis of the 17 patients in the PE treated group and 58 individual warts on the penis of the 18 patients in the PB treated group. Based on the response of individual warts to the 2 treatment regimens, the clearance rate was 42.6% (20/47) for the PE treated group and 25% (15/56) for the PB treated group after 1 week treatment (ns). At 6 weeks follow-up, the clearance rate for the PE treated group and the PB treated group were 85.1% (40/47) and 73.2% (41/56) respectively (ns). Skin irritation including superficial erosions, pain and itch were observed in 47% (8/17) in patients treated with PE compared to 38.9% (7/18) in patients treated with PB (ns) during the 6 weeks follow-up period. The clearance rate of patients treated with PE (0.25%) was compared to those treated with PE (0.5%). Four out of six of PE (0.25%) treated patients had clearance of warts after 1 week and 100% clearance at the end of 6 weeks. None experienced any skin irritation.
This study demonstrates that 0.5% podophyllin (and possibly 0.25% podophyllin) in ethanol is effective in eradicating penile warts. It can be used by patients for self-treatment at home with greater convenience and is more cost effective than the conventional podophyllin 25% in tincture benzoin paint.
本研究的目的是：1）确定乙醇中0.5%[鬼臼树脂（0.5%）]和0.25%[鬼臼树脂（0.25%）]（PE）以4天为间隔连续自我涂抹3天是否与临床每两周应用的25%鬼臼树脂酊剂安息香（PB）治疗阴茎疣效果相同；2）确定PE是否比PB引起的皮肤刺激更少。
1周后，PE（0.5%）治疗组阴茎疣清除率为36.4%（4/11），PE（0.25%）治疗组为66.7%（4/6），PB治疗组为33.3%（6/18）（无显著性差异）。PE（0.5%）治疗组、PE（0.25%）治疗组和PB治疗组在6周时的疣体清除率分别为81.8%（9/11）、100%（6/6）和83.3%（15/17）（无显著性差异）。PE治疗组17例患者阴茎上有47个单个疣体，PB治疗组18例患者阴茎上有58个单个疣体。根据单个疣体对两种治疗方案的反应，1周治疗后PE治疗组清除率为42.6%（20/47），PB治疗组为25%（15/56）（无显著性差异）。在6周随访时，PE治疗组和PB治疗组的清除率分别为85.1%（40/47）和73.2%（41/56）（无显著性差异）。在6周随访期间，PE治疗的患者中有47%（8/17）出现包括浅表糜烂、疼痛和瘙痒在内的皮肤刺激，而PB治疗的患者中有38.9%（7/18）出现（无显著性差异）。比较了PE（0.25%）治疗患者与PE（0.5%）治疗患者的清除率。PE（0.25%）治疗的6例患者中有4例在1周后疣体清除，6周结束时清除率达100%。无人出现任何皮肤刺激。
本研究表明，乙醇中0.5%鬼臼树脂（可能还有0.25%鬼臼树脂）对根除阴茎疣有效。患者可在家自行使用，更加方便，且比传统的25%鬼臼树脂酊剂更具成本效益。
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