某些1-取代的1,2,4-三唑的抗菌作用

Antibacterial effects of some 1-substituted 1,2,4-triazoles.

作者信息

Jantová S, Greif G, Pavlovicová R, Cipák L

机构信息

Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, Bratislava, Slovakia.

出版信息

Folia Microbiol (Praha). 1998;43(1):75-8. doi: 10.1007/BF02815548.

DOI:10.1007/BF02815548

PMID:9569632

Abstract

Seventeen synthetic 1-substituted 1,2,4-triazoles exerted a significant effect on the bacteria B. subtilis, S. aureus, E. coli and P. aeruginosa. The least sensitive to the effects of the triazoles was S. aureus. With all triazole derivatives and their combinations, B. subtilis and P. aeruginosa exhibited IC50 and MIC values several times higher than with ampicillin. The most effective triazoles have a N-phenyl ring or benzimidinoyl ring substituted with one or several chlorine atoms. The highest tested concentration of the three most effective triazoles influenced the specific growth rate.

摘要

17种合成的1-取代-1,2,4-三唑对枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌有显著作用。对三唑作用最不敏感的是金黄色葡萄球菌。对于所有三唑衍生物及其组合，枯草芽孢杆菌和铜绿假单胞菌的IC50和MIC值比氨苄西林高出数倍。最有效的三唑具有被一个或几个氯原子取代的N-苯环或苯并咪唑酰环。三种最有效的三唑的最高测试浓度影响了比生长速率。