某些4,5-二氢-1H-1,2,4-三唑-5-酮的合成及其抗肿瘤活性
Synthesis and antitumor activities of some 4,5-dihydro-1H-1,2,4-triazol-5-ones.
作者信息
Ikizler A A, Ikizler A, Serdar M, Yildirim N
机构信息
Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
出版信息
Acta Pol Pharm. 1997 Sep-Oct;54(5):363-70.
PMID:9584694
Abstract
Eight new 3-alkyl(aryl)-4-arylidenamino-4,5-dihydro-1H-1,2,4-triazol-5 - ones were synthesized and characterised by elemental analysis. 1H NMR, IR and UV spectra. Seven new and 34 recently reported derivatives of 4,5-dihydro-1H-1,2,4 triazol-5-one ring were screened for their antitumor activities.
摘要
合成了8种新的3-烷基（芳基）-4-亚芳基氨基-4,5-二氢-1H-1,2,4-三唑-5-酮，并通过元素分析、1H NMR、IR和UV光谱对其进行了表征。对7种新的和34种最近报道的4,5-二氢-1H-1,2,4-三唑-5-酮环衍生物进行了抗肿瘤活性筛选。
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