5-甲酰基胞苷（f5C）存在于鱿鱼线粒体tRNA(Met)CAU反密码子的摆动位置。
5-formylcytidine (f5C) found at the wobble position of the anticodon of squid mitochondrial tRNA(Met)CAU.
作者信息
Tomita K, Ueda T, Watanabe K
机构信息
Department of Chemistry and Biotechnology, Faculty of Engineering, University of Tokyo, Japan.
出版信息
Nucleic Acids Symp Ser. 1997(37):197-8.
In squid (Loligo breekeri) mitochondria, AUA codons are translated as methionine instead of the universal isoleucine. Here, we present the nucleotide sequence of squid mitochondrial tRNA(Met)CAU. This tRNA(Met)CAU has 5-formylcytidine (f5C) at the wobble position of the anticodon, though it is partially modified. This result indicates the common feature with bovine and nematoda mitochondrial systems in that f5C at the wobble position of the anticodon is very likely involved in translation of AUA codons as methionine in squid mitochondria.
在鱿鱼（剑尖枪乌贼）线粒体中，AUA密码子被翻译为甲硫氨酸，而不是通用的异亮氨酸。在此，我们展示了鱿鱼线粒体tRNA(Met)CAU的核苷酸序列。这种tRNA(Met)CAU在反密码子的摆动位置有5-甲酰胞苷（f5C），尽管它是部分修饰的。这一结果表明与牛和线虫线粒体系统有共同特征，即反密码子摆动位置的f5C很可能参与鱿鱼线粒体中AUA密码子翻译为甲硫氨酸的过程。
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