格拉司琼与氟哌利多预防儿童斜视手术或扁桃体切除术后呕吐的比较。

Comparison of granisetron and droperidol in the prevention of vomiting after strabismus surgery or tonsillectomy in children.

作者信息

Fujii Y, Saitoh Y, Tanaka H, Toyooka H

机构信息

Department of Anaesthesiology, University of Tsukuba Institute of Clinical-Medicine, Ibaraki, Japan.

出版信息

Paediatr Anaesth. 1998;8(3):241-4. doi: 10.1046/j.1460-9592.1998.00206.x.

DOI:10.1046/j.1460-9592.1998.00206.x

PMID:9608970

Abstract

This prospective, randomized, double-blinded study evaluated the antiemetic efficacy of granisetron and droperidol in 80 ASA physical status I children, aged 4-10 years, undergoing strabismus surgery or tonsillectomy with or without adenoidectomy. After anaesthetic induction, the patients received either granisetron (40 micrograms.kg-1, n = 40) or droperidol (50 micrograms.kg-1, n = 40) intravenously. The incidence of vomiting during the first 24h after anaesthesia was 15% and 38% after administering granisetron and droperidol, respectively (P = 0.02). The requirement for rescue antiemetic therapy for the treatment of two or more episodes of vomiting was 0% with granisetron and 18% with droperidol (P = 0.001). In conclusion, granisetron was superior to droperidol in reducing the incidence and frequency of postoperative vomiting in paediatric patients.

摘要

这项前瞻性、随机、双盲研究评估了格拉司琼和氟哌利多对80例年龄在4至10岁、美国麻醉医师协会（ASA）身体状况分级为I级、接受斜视手术或扁桃体切除术（伴或不伴腺样体切除术）的儿童的止吐效果。麻醉诱导后，患者静脉注射格拉司琼（40微克/千克，n = 40）或氟哌利多（50微克/千克，n = 40）。麻醉后24小时内呕吐发生率在给予格拉司琼和氟哌利多后分别为15%和38%（P = 0.02）。因呕吐发作两次或更多次而需要抢救性止吐治疗的比例，格拉司琼组为0%，氟哌利多组为18%（P = 0.001）。总之，在降低儿科患者术后呕吐的发生率和频率方面，格拉司琼优于氟哌利多。