平均红细胞体积/红细胞计数比值对鉴别缺铁性贫血和β地中海贫血特征的预测价值。

Predictive value of MCV/RBC count ratio to discriminate between iron deficiency anaemia and beta thalassaemia trait.

作者信息

Afroz M, Shamsi T S, Syed S

机构信息

Department of Pathology, Karachi Medical and Dental College, Karachi.

出版信息

J Pak Med Assoc. 1998 Jan;48(1):18-9.

PMID:9610082

Abstract

AIM AND BACKGROUND

Two forms of hypochromic microcytic anaemia i.e. iron deficiency and beta-thalassaemia trait are common in our society. This study reports the prevalence of iron deficiency anaemia and beta-thalassaemia trait and predictive value of MCV/RBC count ratio to discriminate between two.

METHODS

Venous blood was taken from 299 students of Karachi Medical & Dental College and Ziauddin Medical University in Na2 EDTA and analyzed by semi-automated Sysmex K-1000 haematology analyzer. MCV/RBC count ratio was used to discriminate between iron deficiency and beta-thalassaemia trait and > 14% was marked as iron deficiency. Hb electrophoresis was used as gold standard test for confirmation. Serum iron and TIBC was performed to confirm iron deficiency anaemia.

RESULTS

Iron deficiency was found in 9% while beta-thalassaemia was seen in 3% students. MCV/RBC count ratio showed a positive predictive value of 91%.

CONCLUSIONS

In areas where iron deficiency anaemia and beta-thalassaemia trait are common, MCV/RBC count ratio can be used to screen out beta-thalassaemia trait.

摘要

目的与背景

缺铁性贫血和β地中海贫血特质这两种低色素小细胞性贫血在我们的社会中很常见。本研究报告了缺铁性贫血和β地中海贫血特质的患病率，以及平均红细胞体积（MCV）/红细胞计数比值对两者进行鉴别的预测价值。

方法

从卡拉奇医学与牙科学院及齐亚丁医科大学的299名学生中采集静脉血，置于乙二胺四乙酸二钠（Na2 EDTA）中，并用半自动希森美康K-1000血液分析仪进行分析。MCV/红细胞计数比值用于鉴别缺铁性贫血和β地中海贫血特质，> 14%被标记为缺铁。血红蛋白电泳用作确诊的金标准检测。检测血清铁和总铁结合力（TIBC）以确诊缺铁性贫血。