曲伐沙星对革兰氏阳性和阴性菌的抗生素后效应
Postantibiotic effect of trovafloxacin against gram-positive and -negative organisms.
作者信息
Pankuch G A, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology, Hershey Medical Center, Pennsylvania 17033, USA.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1503-5. doi: 10.1128/AAC.42.6.1503.
Abstract
Trovafloxacin pneumococcal and staphylococcal postantibiotic effects (PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.4 to 4.4 h. Pneumococcal and staphylococcal postantibiotic sub-MIC effects (PA-SMEs) (0.4 times the MIC) were 2.3 to 3.7 and 2.4 to > 9.2 h, respectively, and E. coli PA-SMEs (0.3 times the MIC) were 6.8 to > 12.0 h. For one P. aeruginosa strain, the PA-SME (0.4 times the MIC) was > 10 h; in the other, rapid bactericidal activity precluded measurement.
摘要
曲伐沙星对肺炎球菌和葡萄球菌的抗生素后效应（PAEs）分别为0.7至1.8小时和0.7至2.4小时。对于大肠杆菌和铜绿假单胞菌，PAEs为2.4至4.4小时。肺炎球菌和葡萄球菌的抗生素后亚抑菌浓度效应（PA - SMEs）（0.4倍MIC）分别为2.3至3.7小时和2.4至>9.2小时，大肠杆菌的PA - SMEs（0.3倍MIC）为6.8至>12.0小时。对于一株铜绿假单胞菌，PA - SMEs（0.4倍MIC）>10小时；另一株则因快速杀菌活性而无法测量。
相似文献
1
Postantibiotic effect of trovafloxacin against gram-positive and -negative organisms.曲伐沙星对革兰氏阳性和阴性菌的抗生素后效应
Antimicrob Agents Chemother. 1998 Jun;42(6):1503-5. doi: 10.1128/AAC.42.6.1503.
2
Postantibiotic effects of gatifloxacin against gram-positive and -negative organisms.加替沙星对革兰氏阳性和阴性菌的抗生素后效应。
Antimicrob Agents Chemother. 1999 Oct;43(10):2574-5. doi: 10.1128/AAC.43.10.2574.
3
Pharmacodynamic studies of trovafloxacin and grepafloxacin in vitro against Gram-positive and Gram-negative bacteria.曲伐沙星和格帕沙星体外抗革兰氏阳性菌和革兰氏阴性菌的药效学研究。
J Antimicrob Chemother. 2000 Jul;46(1):35-43. doi: 10.1093/jac/46.1.35.
4
Postantibiotic effects of garenoxacin (BMS-284756) against 12 gram-positive or -negative organisms.加替沙星（BMS - 284756）对12种革兰氏阳性或阴性菌的抗生素后效应
Antimicrob Agents Chemother. 2003 Mar;47(3):1140-2. doi: 10.1128/AAC.47.3.1140-1142.2003.
5
Postantibiotic effect of trovafloxacin on Pseudomonas aeruginosa.
J Antimicrob Chemother. 1997 Jun;39(6):811-4. doi: 10.1093/jac/39.6.811.
6
7
Postantibiotic effect of tigecycline against 14 gram-positive organisms.替加环素对14种革兰氏阳性菌的抗生素后效应。
Antimicrob Agents Chemother. 2009 Feb;53(2):782-4. doi: 10.1128/AAC.01122-08. Epub 2008 Dec 8.
8
Postantibiotic sub-MIC effects of vancomycin, roxithromycin, sparfloxacin, and amikacin.万古霉素、罗红霉素、司帕沙星和阿米卡星的抗生素后亚抑菌浓度效应。
Antimicrob Agents Chemother. 1992 Sep;36(9):1852-8. doi: 10.1128/AAC.36.9.1852.
9
Antibacterial activity of trovafloxacin against nosocomial Gram-positive and Gram-negative isolates.曲伐沙星对医院内革兰氏阳性和革兰氏阴性分离株的抗菌活性。
J Antimicrob Chemother. 1997 Jun;39 Suppl B:29-34. doi: 10.1093/jac/39.suppl_2.29.
10
Postantibiotic effects of E-4868 and OPC-17116.E-4868和OPC-17116的抗生素后效应。
J Antimicrob Chemother. 1993 Dec;32(6):916-7. doi: 10.1093/jac/32.6.916.
引用本文的文献
1
Postantibiotic, postantibiotic sub-MIC, and subinhibitory effects of PGE-9509924, ciprofloxacin, and levofloxacin.PGE - 9509924、环丙沙星和左氧氟沙星的抗生素后效应、抗生素后亚抑菌浓度效应及亚抑菌效应。
Antimicrob Agents Chemother. 2003 Oct;47(10):3352-6. doi: 10.1128/AAC.47.10.3352-3356.2003.
2
In vitro activity of trovafloxacin against Bacteroides fragilis in mixed culture with either Escherichia coli or a vancomycin- resistant strain of Enterococcus faecium determined by an anaerobic time-kill technique.采用厌氧时间杀菌技术测定曲伐沙星在与大肠杆菌或耐万古霉素屎肠球菌混合培养时对脆弱拟杆菌的体外活性。
Antimicrob Agents Chemother. 2001 Jan;45(1):243-51. doi: 10.1128/AAC.45.1.243-251.2001.
3
Postantibiotic effect and postantibiotic sub-MIC effect of quinupristin-dalfopristin against gram-positive and -negative organisms.奎奴普丁-达福普汀对革兰氏阳性和阴性菌的抗生素后效应及抗生素后亚抑菌浓度效应
Antimicrob Agents Chemother. 1998 Nov;42(11):3028-31. doi: 10.1128/AAC.42.11.3028.
本文引用的文献
1
Postantibiotic effect of trovafloxacin on Pseudomonas aeruginosa.
J Antimicrob Chemother. 1997 Jun;39(6):811-4. doi: 10.1093/jac/39.6.811.
2
In vitro activities of quinolones, beta-lactams, tobramycin, and trimethoprim-sulfamethoxazole against nonfermentative gram-negative bacilli.喹诺酮类、β-内酰胺类、妥布霉素及甲氧苄啶-磺胺甲恶唑对非发酵革兰氏阴性杆菌的体外活性
Antimicrob Agents Chemother. 1996 Jun;40(6):1412-8. doi: 10.1128/AAC.40.6.1412.
3
Activity of CP 99,219 (trovafloxacin) compared with ciprofloxacin, sparfloxacin, clinafloxacin, lomefloxacin and cefuroxime against ten penicillin-susceptible and penicillin-resistant pneumococci by time-kill methodology.采用时间杀菌法比较CP 99,219（曲伐沙星）与环丙沙星、司帕沙星、克林沙星、洛美沙星及头孢呋辛对10株青霉素敏感和青霉素耐药肺炎球菌的活性。
J Antimicrob Chemother. 1996 Jan;37(1):77-84. doi: 10.1093/jac/37.1.77.
4
Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral doses to healthy male volunteers.新型喹诺酮类抗生素曲伐沙星（CP-99,219）在健康男性志愿者单次口服给药后的药代动力学及安全性研究。
J Antimicrob Chemother. 1995 Aug;36(2):385-94. doi: 10.1093/jac/36.2.385.
5
Pharmacodynamics of antimicrobial agents as a basis for determining dosage regimens.抗菌药物的药效学作为确定给药方案的基础。
Eur J Clin Microbiol Infect Dis. 1993;12 Suppl 1:S6-8. doi: 10.1007/BF02389870.
6
In vitro activity of CP-99,219, a new fluoroquinolone, against clinical isolates of gram-positive bacteria.新型氟喹诺酮类药物CP-99,219对革兰氏阳性菌临床分离株的体外活性
Antimicrob Agents Chemother. 1993 Feb;37(2):366-70. doi: 10.1128/AAC.37.2.366.
7
Studies on the postantibiotic effect and the postantibiotic sub-MIC effect of meropenem.美罗培南的抗生素后效应及抗生素后亚抑菌浓度效应研究。
J Antimicrob Chemother. 1993 Jun;31(6):881-92. doi: 10.1093/jac/31.6.881.
8
The post-antibiotic sub-MIC effect in vitro and in vivo.抗生素后亚抑菌浓度效应的体内外研究
J Antimicrob Chemother. 1993 May;31 Suppl D:159-66. doi: 10.1093/jac/31.suppl_d.159.
9
The post-antibiotic effect.抗生素后效应
J Antimicrob Chemother. 1993 Oct;32(4):519-37. doi: 10.1093/jac/32.4.519.
10
In vitro activity of the new fluoroquinolone CP-99,219.新型氟喹诺酮CP-99,219的体外活性
Antimicrob Agents Chemother. 1994 Nov;38(11):2615-22. doi: 10.1128/AAC.38.11.2615.
Zotero 插件