喜树碱类似物/顺铂：在临床前体内模型系统中对晚期膀胱癌的有效治疗。
Camptothecin analogues/cisplatin: an effective treatment of advanced bladder cancer in a preclinical in vivo model system.
作者信息
Keane T E, El-Galley R E, Sun C, Petros J A, Dillahey D, Gomaa A, Graham S D, McGuire W P
机构信息
Division of Urology, Emory University School of Medicine, Atlanta, Georgia, USA.
出版信息
J Urol. 1998 Jul;160(1):252-6. doi: 10.1016/s0022-5347(01)63099-4.
OBJECTIVE
To evaluate the impact of the camptothecin analogs on human TCC xenograft, both as monotherapy and in combination with cisplatin (CDDP).
MATERIALS AND METHODS
Human transitional cell carcinoma (TCC) xenograft tumor line (DU4184) tested by subrenal capsule assay in 112 nude mice(NM-SRCA). CDDP and the camptothecin analogs irinotecan (CPT-11) and 9-aminocamptothecin(9-AC) were evaluated.
RESULTS
Both of the camptothecin analogs showed significant short term tumor inhibition which translated into enhanced survival. Maximal tumor inhibition (>95%) was achieved when either of the camptothecin analogs was combined with CDDP with minimal host toxicity. This translated into 400% increase in median survival. While all controls were dead 39 days following tumor implantation, none of the combination treated animals had died.
CONCLUSION
The combination of CDDP with these camptothecin analogs is an effective therapy against this model of advanced TCC. These observations suggest potential clinical value.
目的
评估喜树碱类似物作为单一疗法以及与顺铂（CDDP）联合使用时对人移行细胞癌异种移植瘤的影响。
材料与方法
通过肾包膜下测定法在112只裸鼠（NM - SRCA）中测试人移行细胞癌（TCC）异种移植瘤系（DU4184）。评估了顺铂以及喜树碱类似物伊立替康（CPT - 11）和9 - 氨基喜树碱（9 - AC）。
结果
两种喜树碱类似物均显示出显著的短期肿瘤抑制作用，这转化为生存期延长。当任何一种喜树碱类似物与顺铂联合使用时，可实现最大程度的肿瘤抑制（>95%），且宿主毒性最小。这转化为中位生存期增加400%。在肿瘤植入后39天所有对照组动物均死亡，而联合治疗组动物无一死亡。
结论
顺铂与这些喜树碱类似物联合使用是针对这种晚期移行细胞癌模型的有效治疗方法。这些观察结果提示了潜在的临床价值。
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