Lagemann K
Fortschr Med. 1976 Apr 8;94(10):585-6.
The pharmaco-kinetics of angiographic contrast media in the extravascular space, which are largely unknown, were investigated experimentally in dogs. As part of a basic study, using radio-active contrast media, it was possible to determine the concentration and rate of elimination in practically all organs and tissues. Measurements were carried out first after prolonged infusion of the contrast under conditions of balanced flow, and secondly six hours after the end of the infusion. It was therefore possible to determine the inflow and loss of contrast medium in various organs or organ systems. The most commonly used angiographic contrast media in Germany were investigated. Their kinetic behaviour is largely identical, their pattern of distribution and elimination depended principally on the organ or tissue. In another study injections were carried out through angiographic catheters in a "physiological angiographic" manner. Measurements obtained show that distribution and excretion of the contrast medium are independent of the site of injection. The kinetics of the contrast within an organ do not differ, whether it is injected selectively or not. The presence of an entero-hepatic circulation of angiographic contrast media has been demonstrated, but quantitatively it is of little importance.
血管造影剂在血管外间隙的药代动力学在很大程度上尚不清楚，因此在犬身上进行了实验研究。作为一项基础研究的一部分，使用放射性造影剂，可以确定几乎所有器官和组织中的浓度及消除速率。首先在平衡血流条件下长时间输注造影剂后进行测量，其次在输注结束6小时后进行测量。因此，可以确定造影剂在各个器官或器官系统中的流入和流失情况。对德国最常用的血管造影剂进行了研究。它们的动力学行为在很大程度上是相同的，其分布和消除模式主要取决于器官或组织。在另一项研究中，以“生理性血管造影”方式通过血管造影导管进行注射。获得的测量结果表明，造影剂的分布和排泄与注射部位无关。无论是否选择性注射，造影剂在器官内的动力学并无差异。已证实存在血管造影剂的肝肠循环，但从数量上看其重要性不大。
