N-（2-吡啶基）-2-[2（3H）-苯并唑酮-3-基]乙酰胺：合成、镇痛和抗炎活性

N-(2-pyridinyl)-2-[2(3H)-benzazolone-3-yl]acetamides: synthesis, antinociceptive and anti-inflammatory activity.

作者信息

Doğruer D S, Unlü S, Yeşilada E, Fethi Sahin M

机构信息

Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara Turkey.

出版信息

Farmaco. 1997 Dec;52(12):745-50.

PMID:9648280

Abstract

Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis, IR and 1H NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and VII g, j, k, r exhibited relatively high antinociceptive activity. In addition, compounds VII d, f, j, p showed statistically significant anti-inflammatory activity.

摘要

已合成了18种N-(2-吡啶基)-2-[2(3H)-苯并唑酮-3-基]乙酰胺衍生物。通过元素分析、红外光谱和1H核磁共振光谱数据对这些化合物的化学结构进行了阐明，并在小鼠身上测试了它们的抗伤害感受和抗炎活性。化合物VII o表现出最高的抗伤害感受活性，VII g、j、k、r表现出相对较高的抗伤害感受活性。此外，化合物VII d、f、j、p表现出具有统计学意义的抗炎活性。