通过非参数连锁分析，在72个精神分裂症家族中发现10号染色体p14-p11区域存在易感性基因座的进一步证据。
Further evidence for a susceptibility locus on chromosome 10p14-p11 in 72 families with schizophrenia by nonparametric linkage analysis.
作者信息
Schwab S G, Hallmayer J, Albus M, Lerer B, Hanses C, Kanyas K, Segman R, Borrman M, Dreikorn B, Lichtermann D, Rietschel M, Trixler M, Maier W, Wildenauer D B
机构信息
Department of Psychiatry, University of Bonn, Germany.
出版信息
Am J Med Genet. 1998 Jul 10;81(4):302-7.
Recent reports on potential linkage by Faraone and the NIMH Genetics Initiative-Millennium Schizophrenia Consortium [1997: Am J Med Genet 74:557], and by Straub et al. [1997: Am J Med Genet 74:558], prompted us to study chromosome 10 in a sample of 72 families containing 2 or more affected sibs with schizophrenia for additional evidence of linkage. We obtained highest allele sharing for the two markers D10S582 (61.5% allele sharing, chi2 = 7.6, P = 0.0058) and D10S1423 (59% allele sharing, chi2 = 4.76, P = 0.029). D10S1423 is one of the markers with the highest lod scores in the study of Faraone and the NIMH Genetics Initiative-Millennium Schizophrenia Consortium [1997: Am J Med Genet 74:557]. GENEHUNTER analysis revealed a nonparametric lod score (NPL) of 3.2 (P = 0.0007) for the marker D10S1714, which lies in the same region. Multipoint affected sib-pair lod score analysis (identity by descent) calculated by ASPEX revealed a lod score of 1.72 for all possible sib-pair combinations (107) and of 2.13, when only independent sib-pairs (87) were counted. Our study provides further evidence for a potential susceptibility locus for schizophrenia on chromosome 10p.
法拉奥内以及美国国立精神卫生研究所遗传学倡议-千年精神分裂症联盟[1997年：《美国医学遗传学杂志》74:557]，还有施特劳布等人[1997年：《美国医学遗传学杂志》74:558]近期关于潜在连锁关系的报告，促使我们在一个包含72个家庭（每个家庭有2个或更多患精神分裂症的同胞）的样本中研究10号染色体，以寻找连锁关系的更多证据。我们在两个标记D10S582（等位基因共享率为61.5%，卡方 = 7.6，P = 0.0058）和D10S1423（等位基因共享率为59%，卡方 = 4.76，P = 0.029）上获得了最高的等位基因共享。D10S1423是法拉奥内以及美国国立精神卫生研究所遗传学倡议-千年精神分裂症联盟研究[1997年：《美国医学遗传学杂志》74:557]中对数优势分数最高的标记之一。GENEHUNTER分析显示，位于同一区域的标记D10S1714的非参数对数优势分数（NPL）为3.2（P = 0.0007）。通过ASPEX计算的多点患病同胞对对数优势分数分析（同源性）显示，对于所有可能的同胞对组合（107对），对数优势分数为1.72；当只计算独立同胞对（87对）时，对数优势分数为2.13。我们的研究为10号染色体短臂上存在精神分裂症潜在易感基因座提供了进一步证据。
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