Eroğlu A, Unal M, Kocaoğlu H
Department of Surgical Oncology, Ankara University, Medical School, Turkey.
Eur J Surg Oncol. 1998 Aug;24(4):283-7. doi: 10.1016/s0748-7983(98)80007-3.
There is considerable controversy concerning the most appropriate surgical treatment of patients with differentiated thyroid carcinoma (DTC). Although some authors have advocated subtotal thyroidectomy because of the decreased surgical morbidity and the lack of improved survival with a more extensive procedure, total thyroidectomy has been defended by others as a treatment of choice with lower morbidity.
We reviewed 106 consecutive patients who had been treated with total thyroidectomy for DTC to determine the complication rate. Forty-seven patients had primary operations and 59 had reoperations with completion of total thyroidectomy.
Residual tumour in the remnant thyroid tissue was found in 53.8% of patients who underwent prophylactic completion thyroidectomy. Permanent hypoparathyroidism was present in one (0.9%) patient and accidental transient unilateral recurrent laryngeal nerve injury occurred in 2.8% of the entire series. No patient had permanent bilateral recurrent nerve palsy. Furthermore, the risk of complication was not significantly different when comparing primary total thyroidectomy or completion surgery.
We recommend total thyroidectomy as a safe treatment for DTC with a low rate of morbidity.
关于分化型甲状腺癌(DTC)患者最合适的手术治疗方法存在相当大的争议。尽管一些作者主张行甲状腺次全切除术,因为其手术发病率较低,且更广泛的手术并未改善生存率,但另一些人则支持将甲状腺全切除术作为发病率较低的首选治疗方法。
我们回顾了106例连续接受甲状腺全切除术治疗DTC的患者,以确定并发症发生率。47例患者接受初次手术,59例患者接受再次手术并完成甲状腺全切除术。
在接受预防性甲状腺全切除术的患者中,53.8%的患者残余甲状腺组织中发现残留肿瘤。1例(0.9%)患者出现永久性甲状旁腺功能减退,整个系列中有2.8%的患者发生意外短暂性单侧喉返神经损伤。没有患者出现永久性双侧喉返神经麻痹。此外,比较初次甲状腺全切除术或再次手术时,并发症风险没有显著差异。
我们建议将甲状腺全切除术作为治疗DTC的一种安全方法,发病率较低。