产肠毒素大肠杆菌溶血素（hlyA）突变体在无菌仔猪中的致病性
Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets.
作者信息
Moxley R A, Berberov E M, Francis D H, Xing J, Moayeri M, Welch R A, Baker D R, Barletta R G
机构信息
Departments of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583, USA.
出版信息
Infect Immun. 1998 Oct;66(10):5031-5. doi: 10.1128/IAI.66.10.5031-5035.1998.
Abstract
Pigs infected with hemolytic F4(+) strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4(+) enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.
摘要
感染产肠毒素大肠杆菌溶血F4(+)菌株的猪常继发肠道感染而发生败血症。我们检验了这样一个假设：溶血素失活会降低F4(+)产肠毒素大肠杆菌经口接种后在猪体内引起败血症的能力。在无菌仔猪模型中，溶血素结构基因（hlyA）失活并未降低败血症的发生率。
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