γ-羟基丁酸对纤维肌痛患者疼痛、疲劳及α波睡眠异常的影响。初步报告。
Effect of gamma-hydroxybutyrate on pain, fatigue, and the alpha sleep anomaly in patients with fibromyalgia. Preliminary report.
作者信息
Scharf M B, Hauck M, Stover R, McDannold M, Berkowitz D
机构信息
Center for Research in Sleep Disorders, Cincinnati, Ohio, USA.
出版信息
J Rheumatol. 1998 Oct;25(10):1986-90.
OBJECTIVE
To evaluate the effects of using a gamma-hydroxybutyrate (GHB) administered in divided doses at night in 11 patients previously diagnosed with fibromyalgia (FM).
METHODS
Subjects completed daily diaries assessing their pain and fatigue levels and slept in the sleep laboratory before and one month after initiating GHB treatment. Polysomnographic recordings were evaluated for sleep stages, sleep efficiency and the presence of the alpha anomaly in non-REM sleep.
RESULTS
There was a significant improvement in both fatigue and pain, with an increase in slow wave sleep and a decrease in the severity of the alpha anomaly.
CONCLUSION
Further controlled studies are needed to characterize the clinical improvement and the polysomnographic changes we observed.
目的
评估对11名先前被诊断为纤维肌痛（FM）的患者在夜间分剂量使用γ-羟基丁酸（GHB）的效果。
方法
受试者完成每日日记，评估他们的疼痛和疲劳程度，并在开始GHB治疗前及治疗一个月后在睡眠实验室睡觉。对多导睡眠图记录进行评估，以确定睡眠阶段、睡眠效率以及非快速眼动睡眠中α波异常的存在情况。
结果
疲劳和疼痛均有显著改善，慢波睡眠增加，α波异常的严重程度降低。
结论
需要进一步的对照研究来描述我们观察到的临床改善情况和多导睡眠图变化。
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