Grandas F, Traba A, Alonso F, Esteban A
Department of Neurology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Clin Neuropharmacol. 1998 Sep-Oct;21(5):307-11.
To determine whether Botulinum Toxin Type A (BTXA) has an effect on the Central Nervous System, the authors studied the excitability of the blink reflex recovery cycle in 12 patients with blepharospasm before and 3 weeks after unilateral BTXA injections. To avoid recording from severely denervated muscles, the R2 response of the blink reflex was obtained from the untreated orbicularis oculi with both ipsilateral and contralateral supraorbital nerve stimulation. Baseline recovery curves were compared with a control group (n = 11) and showed an enhanced recovery of the R2 component. There were no significant differences between the recovery curves of the R2 component of the blink reflex taken before BTXA treatment and those taken after treatment. This finding confirms that BTXA does not modify the excitability of brainstem interneurons that mediate the bilateral R2 response of the blink reflex in patients with blepharospasm.
为了确定A型肉毒毒素（BTXA）是否对中枢神经系统有影响，作者研究了12例睑痉挛患者在单侧注射BTXA之前和之后3周眨眼反射恢复周期的兴奋性。为避免从严重失神经支配的肌肉记录，通过同侧和对侧眶上神经刺激，从未治疗的眼轮匝肌获得眨眼反射的R2反应。将基线恢复曲线与对照组（n = 11）进行比较，结果显示R2成分的恢复增强。BTXA治疗前和治疗后所测眨眼反射R2成分的恢复曲线之间无显著差异。这一发现证实，BTXA不会改变介导睑痉挛患者眨眼反射双侧R2反应的脑干中间神经元的兴奋性。
