酮咯酸（托拉朵）与硫酸镁用于抑制早产的对比研究。
A comparative study of ketorolac (Toradol) and magnesium sulfate for arrest of preterm labor.
作者信息
Schorr S J, Ascarelli M H, Rust O A, Ross E L, Calfee E L, Perry K G, Morrison J C
机构信息
Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
出版信息
South Med J. 1998 Nov;91(11):1028-32. doi: 10.1097/00007611-199811000-00007.
BACKGROUND
We evaluated the efficacy and safety of ketorolac (Toradol).
METHODS
In this prospective trial, 88 women in confirmed preterm labor at < or =32 weeks' gestation were randomized to receive magnesium sulfate given as an initial 6 g intravenous bolus followed by continuous infusion therapy (2 to 6 g/hr) or intramuscularly administered ketorolac (60 mg loading dose) followed by 30 mg every 6 hours for a maximum of 24 hours.
RESULTS
The study groups were similar with respect to age, parity, cervical status, and gestational age on admission. Ketorolac was more rapid (2.71 hr+/-2.16) in the arrest of preterm labor than was magnesium sulfate (6.22 hr+/-5.65). No patient required discontinuance of either drug due to adverse effects. There was no difference in the incidence of neonatal complications between the two groups.
CONCLUSION
In gestations with preterm labor at <32 weeks, ketorolac appears to be an appropriate first-line tocolytic agent.
背景
我们评估了酮咯酸（痛力克）的疗效和安全性。
方法
在这项前瞻性试验中，88名妊娠小于或等于32周且确诊为早产的女性被随机分组，一组接受硫酸镁治疗，初始静脉推注6克，随后持续输注（2至6克/小时）；另一组接受肌肉注射酮咯酸（负荷剂量60毫克），随后每6小时注射30毫克，最多持续24小时。
结果
研究组在年龄、产次、宫颈状况和入院时的孕周方面相似。酮咯酸在抑制早产方面比硫酸镁更快（2.71小时±2.16）（硫酸镁为6.22小时±5.65）。没有患者因不良反应而需要停用任何一种药物。两组新生儿并发症的发生率没有差异。
结论
在妊娠小于32周的早产中，酮咯酸似乎是一种合适的一线宫缩抑制剂。
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