磷脂酰肌醇3激酶在成肌分化中的重要作用。
An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.
作者信息
Jiang B H, Zheng J Z, Vogt P K
机构信息
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14179-83. doi: 10.1073/pnas.95.24.14179.
Abstract
The oncogene p3k, coding for a constitutively active form of phosphatidylinositol 3-kinase (PI 3-kinase; EC 2.7.1.137), strongly enhances myogenic differentiation in cultures of chicken-embryo myoblasts. It increases the size of the myotubes and induces elevated levels of the muscle-specific proteins MyoD, myosin heavy chain, creatine kinase, and desmin. Inhibition of PI 3-kinase activity with LY294002 or with dominant-negative mutants of PI 3-kinase interferes with myogenic differentiation and with the induction of muscle-specific genes. PI 3-kinase is therefore an upstream mediator for the expression of the muscle-specific genes and is both necessary and rate-limiting for the process of myogenesis.
摘要
致癌基因p3k编码一种组成型活性形式的磷脂酰肌醇3激酶（PI 3激酶；EC 2.7.1.137），它能显著增强鸡胚成肌细胞培养物中的肌源性分化。它增加了肌管的大小，并诱导肌肉特异性蛋白MyoD、肌球蛋白重链、肌酸激酶和结蛋白的水平升高。用LY294002或PI 3激酶的显性负性突变体抑制PI 3激酶活性会干扰肌源性分化以及肌肉特异性基因的诱导。因此，PI 3激酶是肌肉特异性基因表达的上游介质，对于肌生成过程既是必需的也是限速的。
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