青蛙卵的卵裂面会受到强磁场的影响而改变。
Cleavage planes in frog eggs are altered by strong magnetic fields.
作者信息
Denegre J M, Valles J M, Lin K, Jordan W B, Mowry K L
机构信息
Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI 02912, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14729-32. doi: 10.1073/pnas.95.25.14729.
Early cleavages of Xenopus embryos were oriented in strong, static magnetic fields. Third-cleavage planes, normally horizontal, were seen to orient to a vertical plane parallel with a vertical magnetic field. Second cleavages, normally vertical, could also be oriented by applying a horizontal magnetic field. We argue that these changes in cleavage-furrow geometries result from changes in the orientation of the mitotic apparatus. We hypothesize that the magnetic field acts directly on the microtubules of the mitotic apparatus. Considerations of the length of the astral microtubules, their diamagnetic anisotropy, and flexural rigidity predict the required field strength for an effect that agrees with the data. This observation provides a clear example of a static magnetic-field effect on a fundamental cellular process, cell division.
非洲爪蟾胚胎的早期卵裂在强静态磁场中发生定向。通常为水平方向的第三次卵裂平面，被观察到会定向至与垂直磁场平行的垂直平面。通常为垂直方向的第二次卵裂，通过施加水平磁场也能实现定向。我们认为，卵裂沟几何形状的这些变化是由有丝分裂器方向的改变引起的。我们推测磁场直接作用于有丝分裂器的微管。对星体微管长度、其抗磁各向异性以及弯曲刚度的考量，预测了与数据相符的效应所需的场强。这一观察结果为静态磁场对基本细胞过程——细胞分裂的影响提供了一个清晰的例子。
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