通过氨基糖苷4'-腺苷酸转移酶和2''-腺苷酸转移酶进行酶促腺苷酸化作为测定血清中氨基糖苷类抗生素浓度的一种方法。
Enzymatic adenylylation by aminoglycoside 4'-adenylytransferase and 2"-adenylyltransferase as a means of determining concentrations of aminoglycoside antibiotics in serum.
作者信息
Santanam P, Kayser F H
出版信息
Antimicrob Agents Chemother. 1976 Oct;10(4):664-7. doi: 10.1128/AAC.10.4.664.
Abstract
A fast and accurate enzymatic estimation of the concentration of aminoglycoside antiobiotics in serum is given by aminoglycoside 4'-adenylyltransferase (synonym: tobramycin adenylyltransferase), a new enzyme recently found in tobramycin-resistant staphylococci (P. Santanam and F. H. Kayser, J. Infect. Dis. [Suppl.], in press). This enzyme is useful in assaying the kanamycins, the butirosins, amikacin, ribostamycin and, if required, the neomycins, tobramycin, and paromomycin. In combination with the assay using aminoglycoside 2''-adenylyltransferase (synonym: gentamicin adenylyltransferase) to determine the level of gentamicin, sisomicin, and tobramycin, a convenient method to estimate a wide range of aminoglycoside antibiotics in patients' sera is described.
摘要
氨基糖苷4'-腺苷酸转移酶（同义词：妥布霉素腺苷酸转移酶）可快速准确地酶法测定血清中氨基糖苷类抗生素的浓度，这是一种最近在耐妥布霉素葡萄球菌中发现的新酶（P. 桑塔纳姆和F. H. 凯泽，《传染病杂志》[增刊]，即将发表）。该酶可用于检测卡那霉素、丁胺卡那霉素、阿米卡星、核糖霉素，如有需要，还可检测新霉素、妥布霉素和巴龙霉素。结合使用氨基糖苷2''-腺苷酸转移酶（同义词：庆大霉素腺苷酸转移酶）测定庆大霉素、西索米星和妥布霉素水平的检测方法，描述了一种方便的方法来估计患者血清中多种氨基糖苷类抗生素的含量。
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Enzymatic adenylylation by aminoglycoside 4'-adenylytransferase and 2"-adenylyltransferase as a means of determining concentrations of aminoglycoside antibiotics in serum.通过氨基糖苷4'-腺苷酸转移酶和2''-腺苷酸转移酶进行酶促腺苷酸化作为测定血清中氨基糖苷类抗生素浓度的一种方法。
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Infect Immun. 1970 Jan;1(1):109-19. doi: 10.1128/iai.1.1.109-119.1970.
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Simplified, accurate method for antibiotic assay of clinical specimens.临床标本抗生素检测的简化、准确方法。
Appl Microbiol. 1966 Mar;14(2):170-7. doi: 10.1128/am.14.2.170-177.1966.
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Enzymatic acetylation as a means of determining serum aminoglycoside concentrations.酶促乙酰化法作为测定血清氨基糖苷类药物浓度的一种手段。
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