趋化因子生长调节致癌基因-α促进脊髓少突胶质前体细胞增殖。
The chemokine growth-regulated oncogene-alpha promotes spinal cord oligodendrocyte precursor proliferation.
作者信息
Robinson S, Tani M, Strieter R M, Ransohoff R M, Miller R H
机构信息
Department of Neurosurgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA.
出版信息
J Neurosci. 1998 Dec 15;18(24):10457-63. doi: 10.1523/JNEUROSCI.18-24-10457.1998.
Chemokines, (chemotactic cytokines) are a family of regulatory molecules involved in modulating inflammatory responses. Here we demonstrate that the chemokine growth-regulated oncogene-alpha (GRO-alpha) is a potent promoter of oligodendrocyte precursor proliferation. The proliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, platelet derived growth factor (PDGF), is dramatically enhanced by GRO-alpha present in spinal cord conditioned medium. One source of GRO-alpha is a subset of spinal cord astrocytes. Cultures of astrocytes contain GRO-alpha mRNA and protein and secrete biologically active concentrations of GRO-alpha. In postnatal spinal cord white matter the location of GRO-alpha-immunoreactive cells is developmentally regulated: GRO-alpha+ cells first appear in ventral and later in dorsal spinal cord white matter. These results suggest that localized proliferation of oligodendrocytes is mediated by synergy between PDGF and GRO-alpha.
趋化因子（化学趋化细胞因子）是一类参与调节炎症反应的调节分子。在此我们证明趋化因子生长调节致癌基因α（GRO-α）是少突胶质细胞前体增殖的有力促进剂。脊髓条件培养基中存在的GRO-α可显著增强未成熟脊髓少突胶质细胞前体对其主要有丝分裂原血小板衍生生长因子（PDGF）的增殖反应。GRO-α的一个来源是脊髓星形胶质细胞的一个亚群。星形胶质细胞培养物含有GRO-α mRNA和蛋白质，并分泌具有生物活性浓度的GRO-α。在出生后脊髓白质中，GRO-α免疫反应性细胞的位置受发育调节：GRO-α+细胞首先出现在脊髓腹侧白质，随后出现在背侧白质。这些结果表明，少突胶质细胞的局部增殖是由PDGF和GRO-α之间的协同作用介导的。
Zotero 插件