Triple helix stabilization properties of oligonucleotides containing 8-amino-2'-deoxyguanosine.
作者信息
Güimil García R, Bachi A, Eritja R, Luque F J, Orozco M
机构信息
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
出版信息
Bioorg Med Chem Lett. 1998 Nov 3;8(21):3011-6. doi: 10.1016/s0960-894x(98)00537-x.
PMID:9873666
Abstract
Analysis of the Hoogsteen base pairs of guanine and 8-aminoguanine with cytosine in the gase phase shows a strong stabilization of the 8-aminoguanine.cytosine base pair due to the formation of an extra H-bond. Melting profiles of oligonucleotides carrying 8-amino-2'-deoxyguanosine confirm the triple helix stabilization properties of 8-aminoguanine.
摘要
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