Bowler S D, Green A, Mitchell C A
Mater Adult Hospital, South Brisbane, QLD.
Med J Aust. 1998;169(11-12):575-8. doi: 10.5694/j.1326-5377.1998.tb123422.x.
To evaluate the effect of Buteyko breathing techniques (BBT) in the management of asthma.
Prospective, blinded, randomised study comparing the effect of BBT with control classes in 39 subjects with asthma. The study was conducted from January 1995 to April 1995.
Subjects recruited from the community, aged 12 to 70 years, with asthma and substantial medication use.
Medication use; morning peak expiratory flow (PEF); forced expiratory volume in one second (FEV1); end-tidal (ET) CO2; resting minute volume (MV); and quality of life (QOL) score, measured at three months.
No change in daily PEF or FEV1 was noted in either group. At three months, the BBT group had a median reduction in daily beta 2-agonist dose of 904 micrograms (range, 29 micrograms to 3129 micrograms), whereas the control group had a median reduction of 57 micrograms (range, -2343 micrograms to 1143 micrograms) (P = 0.002). Daily inhaled steroid dose fell 49% (range, -100% to 150%) for the BBT group and 0 (range, -82% to +100%) for the control group (P = 0.06). A trend towards greater improvement in QOL score was noted for BBT subjects (P = 0.09). Initial MV was high and similar in both groups; by three months, MV was lower in the BBT group than in the control group (P = 0.004). ET CO2 was low in both groups and did not change with treatment.
Those practising BBT reduced hyperventilation and their use of beta 2-agonists. A trend toward reduced inhaled steroid use and better quality of life was observed in these patients without objective changes in measures of airway calibre.
评估布泰科呼吸法(BBT)对哮喘的治疗效果。
前瞻性、双盲、随机研究,比较BBT与对照课程对39例哮喘患者的治疗效果。研究于1995年1月至1995年4月进行。
从社区招募年龄在12至70岁之间、患有哮喘且大量使用药物的受试者。
药物使用情况;晨间呼气峰值流速(PEF);一秒用力呼气容积(FEV1);呼气末(ET)二氧化碳;静息分钟通气量(MV);以及三个月时的生活质量(QOL)评分。
两组的每日PEF或FEV1均无变化。三个月时,BBT组每日β2激动剂剂量的中位数减少了904微克(范围为29微克至3129微克),而对照组的中位数减少了57微克(范围为-2343微克至1143微克)(P = 0.002)。BBT组每日吸入性类固醇剂量下降了49%(范围为-100%至150%),对照组下降了0(范围为-82%至+100%)(P = 0.06)。BBT受试者的QOL评分有更大改善的趋势(P = 0.09)。两组初始MV均较高且相似;到三个月时,BBT组的MV低于对照组(P = 0.004)。两组ET二氧化碳均较低,且治疗后未发生变化。
采用BBT的患者过度通气情况及β2激动剂的使用减少。在这些患者中观察到吸入性类固醇使用减少和生活质量改善的趋势,但气道管径指标无客观变化。