脊椎动物神经系统中的可塑性与干细胞

Plasticity and stem cells in the vertebrate nervous system.

作者信息

Panchision D, Hazel T, McKay R

机构信息

Laboratory of Molecular Biology National Institute of Neurological Disorders and Stroke 36 Convent Drive, MSC 4092 Bethesda MD 20892-4092 USA.

出版信息

Curr Opin Cell Biol. 1998 Dec;10(6):727-33. doi: 10.1016/s0955-0674(98)80114-2.

DOI:10.1016/s0955-0674(98)80114-2

PMID:9914183

Abstract

How and when do vertebrate neural precursor cells choose their fates? While some studies suggest a series of commitments on the road to fate choice, many recent experiments indicate that precursor fate choices can often be changed. Additionally, the identification of common gene control mechanisms in precursors suggest that these cells share fundamental properties throughout development.

摘要

脊椎动物神经前体细胞如何以及何时决定其命运？虽然一些研究表明在命运选择的道路上存在一系列的定向分化过程，但最近的许多实验表明，前体细胞的命运选择往往是可以改变的。此外，在前体细胞中对共同基因控制机制的识别表明，这些细胞在整个发育过程中具有共同的基本特性。