细胞遗传学、ras基因和p53：犬类肿瘤（血管外皮细胞瘤、肥大细胞瘤、组织细胞瘤、绿色瘤）病例研究

Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).

作者信息

Mayr B, Reifinger M, Brem G, Feil C, Schleger W

机构信息

Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.

出版信息

J Hered. 1999 Jan-Feb;90(1):124-8. doi: 10.1093/jhered/90.1.124.

DOI:10.1093/jhered/90.1.124

PMID:9987918

Abstract

Four case reports of mesenchymal neoplasms showing chromosomal abnormalities are presented. In a case of hemangiopericytoma trisomy 2 and centric fusion 19;21 were present. In a mastocytoma a deleted chromosome 35 was seen. A homogeneously staining region (HSR) on chromosome 1 was detected in a histiocytoma. Trisomy 5 and monosomy 31 were observed in a case of granulocytic sarcoma (chloroma). The lack of mutations in exons 1 and 2 of oncogenes N-ras, K-ras, and H-ras and exons 5, 6, 7, and 8 of tumor suppressor gene p53 in these four patients and in a larger series of investigated dogs (25 hemangiopericytomas, 12 mastocytomas, and 8 histiocytomas) is highlighted.

摘要

本文报告了4例显示染色体异常的间充质肿瘤病例。在1例血管外皮细胞瘤中，存在2号染色体三体和19;21着丝粒融合。在1例肥大细胞瘤中，可见35号染色体缺失。在1例组织细胞瘤中，检测到1号染色体上的均匀染色区（HSR）。在1例粒细胞肉瘤（绿色瘤）中观察到5号染色体三体和31号染色体单体。强调了这4例患者以及更多系列研究犬（25例血管外皮细胞瘤、12例肥大细胞瘤和8例组织细胞瘤）中癌基因N-ras、K-ras和H-ras的外显子1和2以及肿瘤抑制基因p53的外显子5、6、7和8中无突变。