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  3. 中成药联合传统西药治疗子痫前期的疗效:一项系统评价和贝叶斯网络Meta分析

中成药联合传统西药治疗子痫前期的疗效:一项系统评价和贝叶斯网络Meta分析

文献检索匿名用户发表于 2025年10月23日 09:540阅读
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中成药联合传统西药治疗子痫前期的疗效:一项系统评价和贝叶斯网络Meta分析

关于中成药联合传统西药治疗子痫前期的疗效,最近一项系统评价和贝叶斯网络Meta分析的研究提供了重要的见解。子痫前期(PE)是一种妊娠相关的高血压疾病,通常会导致严重的母婴并发症。传统的西医治疗(CTs)虽然能够帮助管理该病症,但也伴随着一些副作用,例如剖宫产率和医源性早产的增加。

本研究的目的是评估11种中成药(CPMs)与传统西药联合治疗子痫前期的有效性。研究者对多种数据库进行了综合搜索,纳入了总共61项研究,涉及7044名患有子痫前期的患者,运用Bayesian网络Meta分析方法对这些研究进行了比较和排名。结果表明,所有中成药在降低血压、减少24小时尿蛋白水平以及改善妊娠结果方面均显示出了积极效应。

具体而言,Antelope Horn Oral Liquid、Astragalus Injection和Bushen Jianpi Huoxue Granules的联合使用在降低血压和尿蛋白水平方面特别有效。Compound Danshen Injection在改善妊娠结果方面则表现突出,包括提高新生儿出生体重以及降低新生儿窒息、宫内胎儿窘迫、围产期死亡、胎盘早剥以及产后出血的风险。

因此,研究结果显示,中成药与传统西药联合使用在治疗子痫前期时能够提供比单独使用传统西药更优的临床结果。这一发现强调了结合不同医学体系的潜力,可能在未来的临床实践中对改善子痫前期患者的整体健康发挥重要作用。然而,作者也指出目前的研究结果需要通过高质量、设计良好的临床试验进一步验证,以确保这些初步发现的可靠性和有效性。

References

1Efficacy of Chinese patent medicines combined with conventional western medicine in treatment of preeclampsia: A systematic review and Bayesian network meta-analysis.PubMed

Jiaying Chen, Hao Gu, Hongqin Wu, et al.
J Ethnopharmacol. 2025 Sep 25;353(Pt B):120401. doi: 10.1016/j.jep.2025.120401. Epub 2025 Aug 11.
ETHNOPHARMACOLOGICAL RELEVANCE: Conventional Western treatments (CTs) for preeclampsia (PE) are often linked to serious side effects, such as higher rates of cesarean delivery and medically induced preterm birth. In contrast, recent clinical research has highlighted the potential of Chinese patent medicines (CPMs) as an effective alternative treatment. These studies show that CPMs may help lower blood pressure, reduce 24-h urinary protein levels, and improve pregnancy outcomes. AIM OF THE STUDY: This study evaluates the effectiveness of 11 CPMs used alongside CTs for PE. A network meta-analysis (NMA) was conducted to compare and rank their therapeutic benefits. MATERIALS AND METHODS: A comprehensive search was carried out across multiple databases up to December 2024 to identify studies assessing the effectiveness of CPMs for treating PE. Two independent reviewers screened the studies, extracted data, and evaluated the risk of bias. The NMA was conducted using a Bayesian approach, with statistical analyses performed in StataSE and RStudio. A network diagram, league tables, and SUCRA (surface under the cumulative ranking curve) plots were generated to compare and rank the treatments. This study is registered with PROSPERO (Registration number: CRD42024602456). RESULTS: A total of 61 studies involving 7044 patients with PE were included, examining the effects of 11 different CPMs. All CPMs showed benefits in lowering blood pressure, reducing 24-h urinary protein levels, and improving pregnancy outcomes. Among the treatments, the combination of Antelope Horn Oral Liquid, Astragalus Injection, and Bushen Jianpi Huoxue Granules was particularly effective in reducing blood pressure and urinary protein levels compared to CTs alone. Additionally, Compound Danshen Injection stood out for its superior impact on pregnancy outcomes, including increased neonatal birth weight and reduced risks of neonatal asphyxia, intrauterine fetal distress, perinatal mortality, placental abruption, and postpartum hemorrhage. CONCLUSION: Combining CPMs with CTs for PE was associated with improved clinical outcomes compared to using CTs alone. However, high-quality, well-designed clinical trials should validate these preliminary results.
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