Griffith J D, Nutt J G, Jasinski D R
Clin Pharmacol Ther. 1975 Nov;18(5 Pt 1):563-70. doi: 10.1002/cpt1975185part1563.
dl-Fenfluramine hydrochloride (60, 120, 240 mg), d-amphetamine sulfate (20, 40 mg), and placebo were compared in 8 postaddict volunteers, each dose given orally in random sequence at weekly intervals using a double-blind crossover design. Fenfluramine had little effect on blood pressure and temperature, but caused a marked dilation of pupils, whereas amphetamine was a potent vasopressor and a weak mydriatic. While fenfluramine produced euphoria in some subjects, its overall effects were unpleasant, sedative, and qualitatively different from amphetamine. Three subjects given 240 mg of fenfluramine experienced brief but vivid hallucinogenic episodes characterized by olfactory, visual, and somatic hallucinations, abrupt polar changes in mood, time distortion, fleeting paranoia, and sexual ideation. These observations indicate that fenfluramine is a hallucinogenic agent with a pharmacologic profile in man that is not amphetamine-like.
在8名戒毒后的志愿者中，对盐酸消旋芬氟拉明（60、120、240毫克）、硫酸右旋苯丙胺（20、40毫克）和安慰剂进行了比较，采用双盲交叉设计，每周按随机顺序口服给予每种剂量。芬氟拉明对血压和体温影响不大，但可导致瞳孔明显扩大，而苯丙胺是一种强效血管加压剂和弱散瞳剂。虽然芬氟拉明在一些受试者中产生了欣快感，但其总体效果令人不适、有镇静作用，且在性质上与苯丙胺不同。三名服用240毫克芬氟拉明的受试者经历了短暂但生动的幻觉发作，其特征为嗅觉、视觉和躯体幻觉、情绪突然两极变化、时间扭曲、短暂的偏执观念和性幻想。这些观察结果表明，芬氟拉明是一种致幻剂，其在人体内的药理学特征与苯丙胺不同。
