Borsato M L, Bruniera P, Cusato M P, Spewien K E, Durigon E L, Toporovski J
Santa Casa de São Paulo, SP, Brazil.
J Pediatr (Rio J). 2000 Nov-Dec;76(6):458-60. doi: 10.2223/jped.94.
Transient aplastic crisis is reported in an eight-month old child with sickle cell anemia and acute B19 parvovirus infection. This fact is uncommon in this age. PATIENT AND METHODS: The authors review the literature and describe a clinical case of an eight-month old child with sickle cell anemia presented with profound anemia and reticulocytopenia. His peripheral blood was analyzed for parvovirus B19 using the polymerase chain reaction (PCR), and for anti B19 immunoglobulin Ig M, and Ig G by enzyme-linked immunosorbent assay (ELISA). RESULTS: An eight-month old child with sickle cell anemia was admitted to the hospital with fever and profound anemia (HB = 3.8g/ dl) and reticulocytopenia (2%). A diagnosis of aplastic crisis was established. The results indicate that Ig M and PCR were positive and Ig G negative. The patient needed erytrocyte transfusion, and was discharged on hospital day 4. CONCLUSIONS: The clinical and laboratory features indicate that human parvovirus B19 was the etiologic agent of an aplastic crisis in an eight-month old child. According to the international literature this event is uncommon for this age; in addition, this is the first time it appears in the Brazilian literature.
报告一例患有镰状细胞贫血的8个月大儿童发生短暂性再生障碍危象及急性B19细小病毒感染。这一情况在该年龄段并不常见。患者与方法：作者回顾文献并描述了一例8个月大患有镰状细胞贫血的儿童临床病例，该患儿出现严重贫血和网织红细胞减少。采用聚合酶链反应（PCR）分析其外周血中的细小病毒B19，并通过酶联免疫吸附测定（ELISA）检测抗B19免疫球蛋白IgM和IgG。结果：一名患有镰状细胞贫血的8个月大儿童因发热和严重贫血（血红蛋白=3.8g/dl）及网织红细胞减少（2%）入院。确诊为再生障碍危象。结果显示IgM和PCR呈阳性，IgG呈阴性。患者需要红细胞输血，并于住院第4天出院。结论：临床和实验室特征表明，人细小病毒B19是一名8个月大儿童再生障碍危象的病原体。根据国际文献，这一情况在该年龄段并不常见；此外，这是首次在巴西文献中出现。
