多巴胺转运体基因的A9等位基因会增加酒精依赖女性在酒精戒断期间出现视幻觉的风险。

The A9 allele of the dopamine transporter gene increases the risk of visual hallucinations during alcohol withdrawal in alcohol-dependent women.

作者信息

Limosin Frédéric, Loze Jean-Yves, Boni Claudette, Fedeli Louis-Philippe, Hamon Michel, Rouillon Frédéric, Adès Jean, Gorwood Philip

机构信息

Department of Psychiatry, Albert Chenevier Hospital, 40 rue de Mesly, F-94000 Créteil, France.

出版信息

Neurosci Lett. 2004 May 20;362(2):91-4. doi: 10.1016/j.neulet.2004.02.065.

Abstract

Previous studies have found an association between the A9 allele (nine-copy repeat) of the dopamine transporter (DAT) gene and two complications of alcohol withdrawal, namely delirium tremens (DT) and alcohol withdrawal seizures (AWS). Most of these studies only included male alcohol-dependent patients. Even those that included a small proportion of women did not look at the effect of gender. We compared the frequency of the A9 allele in 64 French Caucasian alcohol-dependent women with a history of alcohol withdrawal complications. Women carrying the A9 allele had more visual hallucinations during withdrawal than those without this allele (P = 0.03). However, women with the A9 allele were not more susceptible to DT or AWS than those without (P = 0.48 and P = 1.00, respectively). Our results suggest that the A9 allele of the DAT gene is involved in vulnerability to alcohol withdrawal complications in women, but that these complications differ from those associated with this polymorphism in alcohol-dependent men.

摘要

先前的研究发现,多巴胺转运体(DAT)基因的A9等位基因(九拷贝重复)与酒精戒断的两种并发症有关,即震颤谵妄(DT)和酒精戒断性癫痫发作(AWS)。这些研究大多只纳入了男性酒精依赖患者。即使那些纳入了一小部分女性的研究也没有考察性别的影响。我们比较了64名有酒精戒断并发症病史的法国白种人酒精依赖女性中A9等位基因的频率。携带A9等位基因的女性在戒断期间出现的视幻觉比未携带该等位基因的女性更多(P = 0.03)。然而,携带A9等位基因的女性并不比未携带该等位基因的女性更容易发生DT或AWS(分别为P = 0.48和P = 1.00)。我们的结果表明,DAT基因的A9等位基因与女性酒精戒断并发症的易感性有关,但这些并发症与酒精依赖男性中与该多态性相关的并发症不同。

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