欧洲抗风湿病联盟(EULAR)早期关节炎管理建议:国际临床研究包括治疗学欧洲常务委员会(ESCISIT)特别工作组报告

EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).

作者信息

Combe B, Landewe R, Lukas C, Bolosiu H D, Breedveld F, Dougados M, Emery P, Ferraccioli G, Hazes J M W, Klareskog L, Machold K, Martin-Mola E, Nielsen H, Silman A, Smolen J, Yazici H

机构信息

Immuno-Rhumatologie, Lapeyronie Hosp, Montpellier, France.

出版信息

Ann Rheum Dis. 2007 Jan;66(1):34-45. doi: 10.1136/ard.2005.044354. Epub 2006 Jan 5.

Abstract

OBJECTIVE

To formulate EULAR recommendations for the management of early arthritis.

METHODS

In accordance with EULAR's "standardised operating procedures", the task force pursued an evidence based approach and an approach based on expert opinion. A steering group comprised of 14 rheumatologists representing 10 European countries. The group defined the focus of the process, the target population, and formulated an operational definition of "management". Each participant was invited to propose issues of interest regarding the management of early arthritis or early rheumatoid arthritis. Fifteen issues for further research were selected by use of a modified Delphi technique. A systematic literature search was carried out. Evidence was categorised according to usual guidelines. A set of draft recommendations was proposed on the basis of the research questions and the results of the literature search.. The strength of the recommendations was based on the category of evidence and expert opinion.

RESULTS

15 research questions, covering the entire spectrum of "management of early arthritis", were formulated for further research; and 284 studies were identified and evaluated. Twelve recommendations for the management of early arthritis were selected and presented with short sentences. The selected statements included recognition of arthritis, referral, diagnosis, prognosis, classification, and treatment of early arthritis (information, education, non-pharmacological interventions, pharmacological treatments, and monitoring of the disease process). On the basis of expert opinion, 11 items were identified as being important for future research.

CONCLUSIONS

12 key recommendations for the management of early arthritis or early rheumatoid arthritis were developed, based on evidence in the literature and expert consensus.

摘要

目的

制定欧洲抗风湿病联盟(EULAR)关于早期关节炎管理的建议。

方法

根据EULAR的“标准化操作程序”,工作组采用基于证据和基于专家意见的方法。一个由代表10个欧洲国家的14名风湿病学家组成的指导小组。该小组确定了该过程的重点、目标人群,并制定了“管理”的操作定义。邀请每位参与者就早期关节炎或早期类风湿关节炎的管理提出感兴趣的问题。通过改良的德尔菲技术选择了15个进一步研究的问题。进行了系统的文献检索。证据按照常规指南进行分类。根据研究问题和文献检索结果提出了一套建议草案。建议的强度基于证据类别和专家意见。

结果

针对进一步研究制定了15个涵盖“早期关节炎管理”全领域的研究问题;共识别并评估了284项研究。选择了12条关于早期关节炎管理的建议,并用简短语句呈现。所选陈述包括早期关节炎的识别、转诊、诊断、预后、分类和治疗(信息、教育、非药物干预、药物治疗以及疾病过程监测)。基于专家意见,确定了11项对未来研究很重要的事项。

结论

基于文献证据和专家共识,制定了12条关于早期关节炎或早期类风湿关节炎管理的关键建议。

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