复位与固定、双极半髋关节置换术和全髋关节置换术的随机对照研究。健康老年患者移位性囊内髋部骨折的治疗。

Randomized comparison of reduction and fixation, bipolar hemiarthroplasty, and total hip arthroplasty. Treatment of displaced intracapsular hip fractures in healthy older patients.

作者信息

Keating J F, Grant A, Masson M, Scott N W, Forbes J F

机构信息

Department of Orthopaedic Trauma, Royal Infirmary, Little France, Old Dalkeith Road, Edinburgh EH16 4SU, Scotland.

出版信息

J Bone Joint Surg Am. 2006 Feb;88(2):249-60. doi: 10.2106/JBJS.E.00215.

Abstract

BACKGROUND

Orthopaedic surgeons vary in their management of displaced intracapsular fractures of the hip in healthy older patients. The aim of this investigation was to determine the functional, clinical, and resource consequences of three different types of surgical treatment.

METHODS

The study was a multicenter randomized controlled trial. Reduction and fixation was compared with bipolar hemiarthroplasty with cement and total hip replacement with cement. Participating surgeons elected to randomize their patients to be treated with either one of the three types of procedures or with either fixation or bipolar hemiarthroplasty. Functional outcomes were measured with a hip-rating questionnaire and the EuroQol health status measure. Clinical outcomes included mortality and complications. The direct health service costs were compared. Participants were followed up for two years.

RESULTS

Two hundred and seven patients were randomized to be treated with one of the three operations, and ninety-one were randomized to be treated with either fixation or bipolar hemiarthroplasty. There were no differences in the mortality rates among the treatment groups. The rate of secondary surgery was highest in the fixation group (39% compared with 5% in the group treated with bipolar hemiarthroplasty and 9% in the group treated with total hip replacement). The fixation group had the worst hip-rating-questionnaire and EuroQol scores at four and twelve months. The total hip replacement group had significantly better functional outcome scores at twenty-four months than the other two groups. Although fixation was initially the least costly procedure, this short-term advantage was eroded by significantly higher costs for subsequent hip-related hospital admissions.

CONCLUSIONS

Arthroplasty is more clinically effective and cost-effective than reduction and fixation in healthy older patients with a displaced intracapsular fracture of the hip. The long-term results of total hip replacement may be better than those of bipolar hemiarthroplasty.

摘要

背景

在健康老年患者髋关节囊内移位骨折的治疗方面,骨科医生的处理方式各不相同。本研究的目的是确定三种不同手术治疗方式的功能、临床及资源利用后果。

方法

本研究为多中心随机对照试验。比较了切开复位内固定术、骨水泥型双极半髋关节置换术和骨水泥型全髋关节置换术。参与研究的外科医生将患者随机分组,接受上述三种手术方式之一,或仅接受内固定术或双极半髋关节置换术。通过髋关节评分问卷和欧洲五维度健康量表评估功能结局。临床结局包括死亡率和并发症。比较了直接医疗服务成本。对参与者进行了两年的随访。

结果

207例患者被随机分配接受三种手术方式之一,91例患者被随机分配接受内固定术或双极半髋关节置换术。各治疗组的死亡率无差异。内固定组二次手术率最高(39%,而双极半髋关节置换术组为5%,全髋关节置换术组为9%)。内固定组在4个月和12个月时髋关节评分问卷及欧洲五维度健康量表得分最差。全髋关节置换术组在24个月时的功能结局评分显著优于其他两组。尽管内固定术最初成本最低,但随后与髋关节相关的住院费用大幅增加,抵消了这一短期优势。

结论

对于健康老年患者髋关节囊内移位骨折,关节置换术在临床疗效和成本效益方面均优于切开复位内固定术。全髋关节置换术的长期效果可能优于双极半髋关节置换术。

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