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使用骨泥重建外耳道外侧壁缺损:长期临床及组织学评估

Reconstruction of outer attic wall defects using bone paté: Long-term clinical and histological evaluation.

作者信息

Bacciu Andrea, Pasanisi Enrico, Vincenti Vincenzo, Di Lella Filippo, Bacciu Salvatore

机构信息

Department of Otolaryngology, University of Parma, Via Gramsci 14, 43100 Parma, Italy.

出版信息

Eur Arch Otorhinolaryngol. 2006 Nov;263(11):983-7. doi: 10.1007/s00405-006-0098-7. Epub 2006 Jun 28.

Abstract

The objective was to evaluate the long-term clinical outcome of the bony outer attic wall reconstruction (scutumplasty) by using autogenous bone paté in a series of patients who underwent canal wall up (CWU) mastoidectomy for middle ear cholesteatoma. In addition, an histological analysis of bone paté graft specimens taken during the second-look procedure 12 months after the first surgery, was carried out. A series of 134 ears from 128 patients with cholesteatoma who underwent staged CWU mastoidectomy and attic reconstruction with bone paté, between 1995 and 2000 inclusive, was retrospectively analyzed. In ten randomly selected ears, biopsies from the newly built outer attic wall were taken during the second-look operation and were microscopically analyzed. At the second stage operation, the bone paté graft was found normal in 64.9% of cases. In 39 (29.1%) patients there was a remarkable hypertrophy of the bone paté which was subsequently thinned out by using a diamond burr. A partial resorption of the bone paté was observed in 4.4% of ears and a total resorption in 1.4%. Residual cholesteatoma was found in 13.4% of ears. At the last follow-up visit, recurrent cholesteatoma was observed in 5.2% of ears. Self cleaning attic retraction pocket occurred in 4.4% of ears. Twelve months after implantation, histologic examination on the newly built bone showed a well-structured bony tissue. In particular, osteoblasts lined bone trabeculae with signs of an active tissue remodeling. In conclusion, the reconstruction of the outer attic wall should be considered a fundamental step when performing a CWU procedure in order to prevent attic retractions and recurrences of cholesteatoma. In our experience, autogenous bone paté graft has demonstrated good long-term results in outer attic wall reconstruction being adaptable, well tolerated, stable and of low cost.

摘要

目的是评估在一系列接受中耳胆脂瘤外耳道上壁(CWU)乳突切除术的患者中,使用自体骨糊进行骨性外鼓室壁重建(盾板成形术)的长期临床结果。此外,对首次手术后12个月二次探查手术时获取的骨糊移植标本进行了组织学分析。回顾性分析了1995年至2000年(含)期间,128例患有胆脂瘤的患者接受分期CWU乳突切除术和骨糊鼓室重建术的134耳。在随机选择的10耳中,二次探查手术时从新建的外鼓室壁取活检并进行显微镜分析。在第二阶段手术中,64.9%的病例中骨糊移植正常。39例(29.1%)患者出现骨糊明显肥大,随后使用金刚砂钻头将其磨薄。4.4%的耳观察到骨糊部分吸收,1.4%的耳完全吸收。13.4%的耳发现残留胆脂瘤。在最后一次随访时,5.2%的耳观察到复发性胆脂瘤。4.4%的耳出现了可自行清洁的鼓室回缩袋。植入12个月后,对新建骨的组织学检查显示为结构良好的骨组织。特别是,成骨细胞排列在骨小梁周围,有活跃的组织重塑迹象。总之,在外耳道上壁手术中,外鼓室壁重建应被视为一个基本步骤,以防止鼓室回缩和胆脂瘤复发。根据我们的经验,自体骨糊移植在外鼓室壁重建中显示出良好的长期效果,具有适应性强、耐受性好、稳定性高和成本低的特点。

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