Xu Yanhui, Tamada Koji, Chen Lieping
Molecular Biology Graduate Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
Immunol Res. 2007;37(1):17-32. doi: 10.1007/BF02686093.
The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.
与LIGHT相关的分子网络由至少七种相互作用的受体和配体组成。最近的研究表明，该网络对先天性免疫和适应性免疫均具有深远的免疫调节功能。实验数据支持这样一种观点，即该网络可能在包括癌症、感染、移植耐受和自身免疫性疾病在内的人类疾病发病机制中也发挥作用。在这篇综述中，我们试图详细剖析每一种分子相互作用，并根据它们在发病机制中的作用以及在人类疾病中可能的治疗潜力将它们整合起来。
