Shahraki Mohammad Reza, Arab Mohammad Reza, Mirimokaddam Ebrahim, Palan Mony Jey
Dept. of Physiology, Zahedn University of Medical Sciences, Faculty of Medicine, Zahedan, Iran.
Dept. of Histology, Zahedn University of Medical Sciences, Faculty of Medicine, Zahedan, Iran.
Iran Biomed J. 2007 Jan;11(1):65-68.
BACKGROUND: Teucrium polium is an analgesic, antidiabetic and antilipeidemic herbal medicament. The aim of this survey was to evaluate the effect of aqueous extract T. polium on liver enzymes linked to liver dysfunction, serum lipids and glucose, in diabetic male rats. METHODS: A total of 20 Sprague-Dawly male rats became diabetic by intraperitoneal injection of streptozotocin (60 mg/kg). the animals were divided randomly into two groups. Experimental group was fed Teucrium polium (50 mg/kg) for a month but control group was received the same volume of distilled water. Liver enzymes, biochemical parameters (cholesterol, triglyceride, low density lipoprotein, alanine transaminase, aspartae transaminase) and glucose were measured by kinetic (Enzymatic) and colorimetric methods. Data obtained were analyzed and mean values were compared by paired student's t-test. The results were expressed as mean +/- SD. Significant differences were set at P < 0.05. RESULTS: Our results showed that in test group, serum glucose values decreased significantly (P < 0.05), but cholesterol, triglyceride, low density lipoprotein, alanine transaminase and aspartae transaminase increased significantly after use of T. polium (P < 0.05). This parameters value did not show any changes in control group. CONCLUSION: Although the aqueous extract of Teucrium polium has strong hypoglycemic properties in experimental animals, but because of some hepatotoxic effects, it is not suitable to use it in human as an antidiabetic agent.
背景：夏香薄荷是一种具有止痛、抗糖尿病和抗血脂作用的草药。本研究旨在评估夏香薄荷水提取物对糖尿病雄性大鼠肝脏功能相关酶、血脂和血糖的影响。 方法：通过腹腔注射链脲佐菌素（60mg/kg）使20只Sprague-Dawly雄性大鼠患糖尿病。将动物随机分为两组。实验组喂食夏香薄荷（50mg/kg）一个月，而对照组给予相同体积的蒸馏水。采用动力学（酶法）和比色法测量肝脏酶、生化参数（胆固醇、甘油三酯、低密度脂蛋白、丙氨酸转氨酶、天冬氨酸转氨酶）和血糖。对获得的数据进行分析，并通过配对学生t检验比较平均值。结果以平均值±标准差表示。设定显著性差异为P<0.05。 结果：我们的结果表明，在测试组中，血清葡萄糖值显著降低（P<0.05），但使用夏香薄荷后胆固醇、甘油三酯、低密度脂蛋白、丙氨酸转氨酶和天冬氨酸转氨酶显著升高（P<0.05）。对照组中这些参数值未显示任何变化。 结论：虽然夏香薄荷水提取物在实验动物中具有很强的降血糖特性，但由于其一些肝毒性作用，不适合作为抗糖尿病药物在人类中使用。
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