Coornaert Beatrice, Carpentier Isabelle, Beyaert Rudi
Department of Molecular Biology, Ghent University.
J Biol Chem. 2009 Mar 27;284(13):8217-21. doi: 10.1074/jbc.R800032200. Epub 2008 Nov 13.
Inappropriate functioning of the immune system is linked to immune deficiency, autoimmune disease, and cancer. It is therefore not surprising that intracellular immune signaling pathways are tightly controlled. One of the best studied transcription factors in immune signaling is NF-kappaB, which is activated by multiple receptors and regulates the expression of a wide variety of proteins that control innate and adaptive immunity. A20 is an early NF-kappaB-responsive gene that encodes a ubiquitin-editing protein that is involved in the negative feedback regulation of NF-kappaB signaling. Here, we discuss the mechanism of action of A20 and its role in the regulation of inflammation and immunity.
免疫系统的功能异常与免疫缺陷、自身免疫性疾病和癌症相关。因此，细胞内免疫信号通路受到严格调控也就不足为奇了。免疫信号中研究最深入的转录因子之一是核因子κB（NF-κB），它被多种受体激活，并调节控制先天性和适应性免疫的多种蛋白质的表达。A20是一个早期NF-κB反应基因，编码一种泛素编辑蛋白，参与NF-κB信号的负反馈调节。在这里，我们讨论A20的作用机制及其在炎症和免疫调节中的作用。
