在使用 3.0T MRI 和 Lyon-Schuss 射线照相的多中心研究中，骨关节炎患者与健康对照者的区域性软骨形态和关节间隙宽度变化。
Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography.
机构信息
Pfizer Global Research and Development, New London, Connecticut, USA.
出版信息
Ann Rheum Dis. 2010 Jan;69(1):155-62. doi: 10.1136/ard.2008.099762.
OBJECTIVE
Cartilage morphology displays sensitivity to change in osteoarthritis (OA) with quantitative MRI (qMRI). However, (sub)regional cartilage thickness change at 3.0 Tesla (T) has not been directly compared with radiographic progression of joint space narrowing in OA participants and non-arthritic controls.
METHODS
A total of 145 women were imaged at 7 clinical centres: 86 were non-obese and asymptomatic without radiographic OA and 55 were obese with symptomatic and radiographic OA (27 Kellgren-Lawrence grade (KLG)2 and 28 KLG3). Lyon-Schuss (LS) and fixed flexion (FF) radiographs were obtained at baseline, 12 and 24 months, and coronal spoiled gradient echo MRI sequences at 3.0 T at baseline, 6, 12 and 24 months. (Sub)regional, femorotibial cartilage thickness and minimum joint space width (mJSW) in the medial femorotibial compartment were measured and the standardised response means (SRMs) determined.
RESULTS
At 6 months, qMRI demonstrated a -3.7% "annualised" change in cartilage thickness (SRM -0.33) in the central medial femorotibial compartment (cMFTC) of KLG3 subjects, but no change in KLG2 subjects. The SRM for mJSW in 12-month LS/FF radiographs of KLG3 participants was -0.68/-0.13 and at 24 months was -0.62/-0.20. The SRM for cMFTC changes measured with qMRI was -0.32 (12 months; -2.0%) and -0.48 (24 months; -2.2%), respectively.
CONCLUSIONS
qMRI and LS radiography detected significant change in KLG3 participants at high risk of progression, but not in KLG2 participants, and only small changes in controls. At 12 and 24 months, LS displayed greater, and FF less, sensitivity to change in KLG3 participants than qMRI.
目的
软骨形态学在骨关节炎（OA）的定量 MRI（qMRI）中显示出对变化的敏感性。然而，在 3.0T（T）下，（亚）区域软骨厚度变化尚未直接与 OA 参与者和非关节炎对照者的关节间隙狭窄的放射学进展进行比较。
方法
共对 145 名女性在 7 个临床中心进行了成像：86 名非肥胖且无症状，无放射学 OA，55 名肥胖且有症状和放射学 OA（27 级 Kellgren-Lawrence（KLG）和 28 级 KLG3）。基线时获得 Lyon-Schuss（LS）和固定屈曲（FF）射线照相，12 和 24 个月，基线、6、12 和 24 个月时获得冠状扰相梯度回波 MRI 序列。测量内侧股胫关节间的（亚）区域、股骨胫骨软骨厚度和最小关节间隙宽度（mJSW），并确定标准化反应均值（SRM）。
结果
在 6 个月时，qMRI 显示 KLG3 受试者中央内侧股骨胫骨间室（cMFTC）的软骨厚度“年变化率”为-3.7%（SRM-0.33），而 KLG2 受试者则无变化。KLG3 参与者 12 个月 LS/FF 射线照相 mJSW 的 SRM 为-0.68/-0.13，24 个月为-0.62/-0.20。qMRI 测量的 cMFTC 变化的 SRM 分别为-0.32（12 个月；-2.0%）和-0.48（24 个月；-2.2%）。
结论
qMRI 和 LS 射线照相术在进展风险高的 KLG3 参与者中检测到了显著的变化，但在 KLG2 参与者中未检测到，在对照组中仅检测到微小的变化。在 12 个月和 24 个月时，LS 在 KLG3 参与者中显示出比 qMRI 更高、FF 更低的变化敏感性。
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