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[Artemin与GFRalpha3的表达及其与胰腺癌神经侵犯和转移的相关性]

[Artemin and GFRalpha3 expressions and their relevance to perineural invasiveness and metastasis of pancreatic carcinoma].

作者信息

Zhu Dong-Liang, Luo Di-Lai, Luo Gang, Wang Bo, Gao Ji-Min

机构信息

Department of Hepatobiliary Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Mar;29(3):428-32.

PMID:19304517
Abstract

OBJECTIVE

To investigate the association of artemin and GFRalpha3 expressions with perineural invasion and metastasis of pancreatic carcinoma.

METHODS

Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were used to detect the expression of artemin and GFRalpha3 in pancreatic carcinoma tissues, adjacent tissues and normal pancreas tissues, and the relevance of artemin and GFRalpha3 expressions to the perineural invasion and metastasis of pancreatic carcinoma were analyzed.

RESULTS

The positivity rates of artemin and GFRalpha3 expressions were 72.09% and 67.44% in pancreatic carcinoma, respectively, significantly higher than those in the adjacent tissue (18.19% and 22.73%). The positivity rates of artemin and GFRalpha3 expressions were significantly higher in patients with perineural invasion than in those without perineural invasion (chi(2)=11.11 and 11.78, respectively, P<0.01). Significantly higher expression of artemin mRNA was noted in pancreatic carcinoma (0.741-/+0.014) than in the normal pancreas tissue (0.101-/+0.031, P<0.05), and patients with perineural invasion showed significantly higher positivity rates of artemin mRNA expression (0.843-/+0.012) than those without perineural invasion (0.512-/+0.017, P<0.05).

CONCLUSION

Artemin and GFRalpha3 expressions may play an important role in perineural invasion of pancreatic carcinoma and can be used a useful indicators for evaluating the biological behavior of pancreatic carcinomas.

摘要

目的

探讨嗜铬粒蛋白A和GFRα3表达与胰腺癌神经侵犯及转移的关系。

方法

采用半定量逆转录聚合酶链反应（RT-PCR）和免疫组织化学法检测胰腺癌组织、癌旁组织及正常胰腺组织中嗜铬粒蛋白A和GFRα3的表达，并分析嗜铬粒蛋白A和GFRα3表达与胰腺癌神经侵犯及转移的相关性。

结果

胰腺癌组织中嗜铬粒蛋白A和GFRα3表达阳性率分别为72.09%和67.44%，显著高于癌旁组织（分别为18.19%和22.73%）。有神经侵犯的患者嗜铬粒蛋白A和GFRα3表达阳性率显著高于无神经侵犯者（χ2分别为11.11和11.78，P<0.01）。胰腺癌组织中嗜铬粒蛋白A mRNA表达（0.741±0.014）显著高于正常胰腺组织（0.101±0.031，P<0.05），有神经侵犯的患者嗜铬粒蛋白A mRNA表达阳性率（0.843±0.012）显著高于无神经侵犯者（0.512±0.017，P<0.05）。

结论

嗜铬粒蛋白A和GFRα3表达可能在胰腺癌神经侵犯中起重要作用，可作为评估胰腺癌生物学行为的有用指标。

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