Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA.
Adv Drug Deliv Rev. 2009 Oct 5;61(12):988-1006. doi: 10.1016/j.addr.2009.07.005. Epub 2009 Jul 28.
Electrospinning is a versatile technique that enables the development of nanofiber-based biomaterial scaffolds. Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix in tissues. Silk is a natural protein with excellent biocompatibility, remarkable mechanical properties as well as tailorable degradability. Integrating these protein polymer advantages with electrospinning results in scaffolds with combined biochemical, topographical and mechanical cues with versatility for a range of biomaterial, cell and tissue studies and applications. This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine. Research challenges and future trends are also discussed.
静电纺丝是一种通用技术，可用于开发基于纳米纤维的生物材料支架。由于它们模拟了组织中原生细胞外基质中某些纤维成分的纳米级特性，因此可以生成用于组织工程和再生医学的支架。丝是一种具有优异生物相容性的天然蛋白质，具有出色的机械性能和可调节的降解性。将这些蛋白质聚合物的优势与静电纺丝相结合，可得到具有综合生物化学、形貌和机械线索的支架，具有多功能性，适用于各种生物材料、细胞和组织研究和应用。本文综述了与丝的静电纺丝相关的研究，包括工艺参数、纺丝纤维的后处理、纳米纤维的功能化以及这些材料系统在再生医学中的潜在应用。还讨论了研究挑战和未来趋势。
