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70 与 120 瓦铥:钇铝石榴石 2 微米连续波激光治疗良性前列腺增生:系统的离体评估。

70 vs 120 W thulium:yttrium-aluminium-garnet 2 microm continuous-wave laser for the treatment of benign prostatic hyperplasia: a systematic ex-vivo evaluation.

机构信息

Department of Urology, University Medical Centre Mannheim, Mannheim, Germany.

出版信息

BJU Int. 2010 Aug;106(3):368-72. doi: 10.1111/j.1464-410X.2009.09059.x. Epub 2009 Nov 13.

Abstract

OBJECTIVE

To evaluate the ablative and haemostatic properties of the recently introduced 120-W thulium:yttrium-aluminium-garnet (Tm-YAG) laser and to assess these results against those of the previously introduced 70-W Tm-YAG laser.

MATERIALS AND METHODS

The ex-vivo model of the isolated blood-perfused porcine kidney was used to determine the ablation capacity, haemostatic properties and coagulation depth of a 2 microm continuous-wave Tm-YAG laser. The energy was delivered using a 550-microm and an 800-microm bare-ended fibre. The results of the recently introduced 120-W Tm-YAG were compared to the established 70-W device. Kidney tissue was embedded for histological evaluation. After staining (haematoxylin and eosin, H & E; and NADH) of the specimen, the coagulation zone and depth of the necrotic tissue layer were measured.

RESULTS

With increased power output, the mean (sd) rate of vaporization of tissue increased, from 9.80 (3.03) g/10 min at 70 W to 16.41 (5.2) g/10 min at 120 W using the 550 microm fibre. The total amount of ablated tissue using the 800 microm fibre was lower than with the 550 microm fibre. With increasing power output the bleeding rate remained stable in either group. Tissue penetration remained shallow, even with increasing power output. In contrast to H&E staining, where the coagulation zone was measured, NADH staining showed an inner zone of necrotic tissue, again with no difference between the 70- and the 120-W Tm-YAG.

CONCLUSION

The 120-W Tm-YAG offers significantly higher ablation rates than the 70-W device, and despite the increased rate of ablation with the 120-W Tm-YAG, the bleeding rate and depth of tissue penetration were comparable to those using the 70-W device.

摘要

目的

评估新引入的 120W 掺钬钇铝石榴石(Tm-YAG)激光的消融和止血性能,并将这些结果与之前引入的 70W Tm-YAG 激光进行比较。

材料与方法

使用离体灌注猪血的猪肾模型来确定 2μm 连续波 Tm-YAG 激光的消融能力、止血性能和凝固深度。采用 550μm 和 800μm 裸端光纤传输能量。将新引入的 120W Tm-YAG 激光的结果与已建立的 70W 设备进行比较。对肾组织进行包埋以进行组织学评估。对标本进行染色(苏木精和伊红、H & E;和 NADH)后,测量凝固区和坏死组织层的深度。

结果

随着功率输出的增加,组织的平均(标准差)蒸发率增加,使用 550μm 光纤时,从 70W 时的 9.80(3.03)g/10min 增加到 120W 时的 16.41(5.2)g/10min。使用 800μm 光纤时,总消融组织量低于 550μm 光纤。在任何一组中,随着功率输出的增加,出血率保持稳定。即使增加功率输出,组织穿透仍然较浅。与 H&E 染色相比,其中测量了凝固区,NADH 染色显示了坏死组织的内层,70W 和 120W Tm-YAG 之间也没有差异。

结论

120W Tm-YAG 提供的消融率明显高于 70W 设备,尽管 120W Tm-YAG 的消融率增加,但出血率和组织穿透深度与 70W 设备相当。

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