匹兹堡化合物 B 与脑脊液、血浆和尿液中的阿尔茨海默病生物标志物：一项探索性研究。
Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study.
机构信息
Department of Public Health/Geriatrics, Uppsala University, Sweden.
出版信息
Dement Geriatr Cogn Disord. 2010;29(3):204-12. doi: 10.1159/000281832. Epub 2010 Mar 20.
BACKGROUND
The positron emission tomography (PET) radiotracer Pittsburgh Compound-B (PIB) is an in vivo ligand for measuring beta-amyloid (Abeta) load. Associations between PET PIB and cerebrospinal fluid (CSF) Abeta1-42 and apolipoprotein E epsilon4 (APOE epsilon4) have been observed in several studies, but the relations between PIB uptake and other biomarkers of Alzheimer's disease (AD) are less investigated.
METHOD
PET PIB, PET 18Fluoro-2-deoxy-D-glucose and different AD biomarkers were measured twice in CSF, plasma and urine 12 months apart in 10 patients with a clinical diagnosis of mild to moderate AD.
RESULTS
PIB retention was constant over 1 year, inversely related to low CSF Abeta1-42 (p = 0.01) and correlated positively to the numbers of the APOE epsilon4 allele (0, 1 or 2) (p = 0.02). There was a relation between mean PIB retention and CSF ApoE protein (r = -0.59, p = 0.07), and plasma cystatin C (r = -0.56, p = 0.09).
CONCLUSION
PIB retention is strongly related to CSF Abeta1-42, and to the numbers of the APOE epsilon4 allele.
背景
正电子发射断层扫描（PET）示踪剂匹兹堡化合物-B（PIB）是一种用于测量β-淀粉样蛋白（Abeta）负荷的体内配体。在几项研究中已经观察到 PET PIB 与脑脊液（CSF）Abeta1-42 和载脂蛋白 E ɛ4（APOE ɛ4）之间存在关联，但 PIB 摄取与其他阿尔茨海默病（AD）生物标志物之间的关系研究较少。
方法
10 例临床诊断为轻度至中度 AD 的患者在 12 个月内两次测量 CSF、血浆和尿液中的 PET PIB、18F 氟代-2-脱氧-D-葡萄糖和不同的 AD 生物标志物。
结果
PIB 保留率在 1 年内保持稳定，与低 CSF Abeta1-42 呈负相关（p = 0.01），与 APOE ɛ4 等位基因（0、1 或 2）的数量呈正相关（p = 0.02）。PIB 保留率与 CSF ApoE 蛋白（r = -0.59，p = 0.07）和血浆胱抑素 C（r = -0.56，p = 0.09）之间存在关系。
结论
PIB 保留与 CSF Abeta1-42 以及 APOE ɛ4 等位基因的数量密切相关。
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