Tsibulevskii A Yu, Dubovaya T K, Sokolinskii B Z, Medovyi V S, Pyatnitskii A M
Russian State Medical University, Moscow, Russia.
Neurosci Behav Physiol. 2010 May;40(4):369-74. doi: 10.1007/s11055-010-9266-8. Epub 2010 Mar 26.
Acute massive hemorrhage in rats is accompanied by consistent changes in the morphofunctional characteristics of erythrocytes: diameter, area, polarization, form factor, and integral and specific optical density. Thus, young initially intact rats showed significant increases in the mean diameter, area, and integral optical density at particular time points after hemorrhage, along with increases in erythrocyte polarization and form factor. Vagotomized rats of the same age group responded to hemorrhage only with an increase in the form factor. Initially intact aged rats in these conditions showed increases in the integral optical density and form factor. Aged vagotomized rats showed increases in erythrocyte mean diameter and area. The nature and dynamics of responses to hemorrhage in initially intact and vagotomized (14 days post-operative) animals were significantly different and had age-dependent features. Thus, the most marked changes in young initially intact animals were seen 3-10 h after hemorrhage, while maximum changes were seen at 3 and 96 h in vagotomized animals of the same age. In aged initially intact rats, the greatest changes in study parameters were seen at 3 and 96 h, while the greatest changes were seen in vagotomized rats at 3 and 24 h. The physiological mechanisms of these pathological states are discussed.
直径、面积、极化、形态因子以及积分光密度和比光密度。因此，最初健康的年轻大鼠在出血后的特定时间点，平均直径、面积和积分光密度显著增加，同时红细胞极化和形态因子也增加。相同年龄组的迷走神经切断大鼠对出血的反应仅表现为形态因子增加。在这些条件下，最初健康的老年大鼠积分光密度和形态因子增加。老年迷走神经切断大鼠红细胞平均直径和面积增加。最初健康和迷走神经切断（术后14天）动物对出血反应的性质和动态有显著差异，且具有年龄依赖性特征。因此，最初健康的年轻动物在出血后3 - 10小时出现最明显的变化，而相同年龄的迷走神经切断动物在3小时和96小时出现最大变化。在最初健康的老年大鼠中，研究参数的最大变化出现在3小时和96小时，而迷走神经切断大鼠在3小时和24小时出现最大变化。本文讨论了这些病理状态的生理机制。
